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SARS-CoV-2 variant exposures elicit antibody responses with differential cross-neutralization of established and emerging strains including Delta and Omicron
medRxiv - Infectious Diseases Pub Date : 2021-12-22 , DOI: 10.1101/2021.09.08.21263095
Matthew T Laurie 1 , Jamin Liu 1, 2 , Sara Sunshine 1 , James Peng 3 , Douglas Black 3 , Anthea M Mitchell 1, 4 , Sabrina A Mann 1, 4 , Genay Pilarowski 5, 6 , Kelsey C Zorn 1 , Luis Rubio 3 , Sara Bravo 6 , Carina Marquez 3 , Joseph J Sabatino 7 , Kristen Mittl 7 , Maya Petersen 8 , Diane Havlir 3 , Joseph DeRisi 1, 4
Affiliation  

The wide spectrum of SARS-CoV-2 variants with phenotypes impacting transmission and antibody sensitivity necessitates investigation of the immune response to different spike protein versions. Here, we compare the neutralization of variants of concern, including B.1.617.2 (Delta) and B.1.1.529 (Omicron) in sera from individuals exposed to variant infection, vaccination, or both. We demonstrate that neutralizing antibody responses are strongest against variants sharing certain spike mutations with the immunizing exposure. We also observe that exposure to multiple spike variants increases the breadth of variant cross-neutralization. These findings contribute to understanding relationships between exposures and antibody responses and may inform booster vaccination strategies.

中文翻译:

SARS-CoV-2 变体暴露引发抗体反应,对包括 Delta 和 Omicron 在内的已建立和新兴菌株进行不同的交叉中和

具有影响传播和抗体敏感性的表型的广泛 SARS-CoV-2 变体需要研究对不同刺突蛋白版本的免疫反应。在这里,我们比较了来自暴露于变异感染、疫苗接种或两者的个体血清中的关注变异的中和,包括 B.1.617.2 (Delta) 和 B.1.1.529 (Omicron)。我们证明,中和抗体反应对与免疫暴露共享某些尖峰突变的变体最强。我们还观察到,暴露于多个尖峰变体会增加变体交叉中和的广度。这些发现有助于了解暴露与抗体反应之间的关系,并可能为加强疫苗接种策略提供信息。
更新日期:2021-12-24
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