The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ₁ receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.

中文翻译：

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铜催化对映选择性烯烃碳醚化合成饱和六元环醚

报道了烯醇与苯乙烯的对映选择性铜催化氧化偶联，用于构建二氢吡喃、异色满、吡喃和吗啉。证明了使用这种烯烃碳醚化方法的 σ _{1受体配体的简明形式合成。}配体、溶剂和碱都会影响反应效率。给出了 DFT 过渡态计算。