A novel dopamine-modified epoxysilane was synthesized via a ring-opening reaction. Then, the photosensitizer ZnPc and photothermal-agent polydopamine were simultaneously introduced into nanoparticles by a facile encapsulation-reprecipitation method. The nanoparticles exhibited high photothermal conversion efficiency (η=46.4%) and suitable photostability, apart from the capacity of ¹O₂ generation (Φ_Δ=0.28). Based on the nanoparticles, improved therapeutic efficacy against tumor cells was achieved with synergetic treatment of PDT/PTT, even under hypoxia.

中文翻译：

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用于协同光动力-光热疗法的 ZnPc-聚多巴胺共载纳米颗粒的简便合成

通过开环反应合成了一种新型的多巴胺改性环氧硅烷。然后，通过简便的封装-再沉淀方法将光敏剂 ZnPc 和光热剂聚多巴胺同时引入纳米颗粒中。除了产生¹ O ₂的能力（Φ _Δ =0.28）外，纳米颗粒还表现出高光热转换效率（η = 46.4%）和合适的光稳定性。基于纳米颗粒，即使在缺氧条件下，通过协同治疗 PDT/PTT 也能提高对肿瘤细胞的治疗效果。