Abstract

Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer.

中文翻译：

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甲基乙二醛代谢在癌症中的可能作用

摘要

肿瘤重新编程其新陈代谢以获得优于正常细胞的进化优势。然而，并非所有这些代谢途径都支持能量产生。这些代谢途径的一个例子是甲基乙二醛 (MG) 途径。该途径有助于维持氧化还原状态，并且它可能充当监测细胞内磷酸盐水平的磷酸盐传感器。在这项工作中，我们讨论了 MG 途径的生化步骤并将其与癌症相关联。