Materials Technology ( IF 3.1 ) Pub Date : 2021-09-14 , DOI: 10.1080/10667857.2021.1978640 Gurdev Singh 1 , Soundarapandian Santhanakrishnan 1
ABSTRACT
A bone implant is one of the important areas in biomedical applications where biomaterial like polymers, ceramics and metals plays a deciding role. Polymethyl(methacrylate) (PMMA) is one of the biocompatible materials that can be used for fabricating bone implants. In this work, the combinations of PMMA, PMMA/HA, PMMA/Mg and PMMA/HA/Mg scaffolds were fabricated by the freeze casting process. The variation of pore size, porosity and compressive strength was studied for PMMA and its combinations with HA and Mg. The pore size in all four combinations was greater than 200 µm. This indicates that all four types of scaffolds are suitable for bone implants in their biological functions. The compressive strength of the PMMA/HA (26.08 MPa) scaffold was higher than the cancellous bone. In this work, PMMA/HA scaffold with better pore size and compressive strength was fabricated which has given way to fabricate bone implants in the near future.
中文翻译:
使用冷冻铸造法制备和表征复合 PMMA/HA 支架
摘要
骨植入物是生物医学应用中的重要领域之一,其中聚合物、陶瓷和金属等生物材料起着决定性的作用。聚甲基丙烯酸甲酯 (PMMA) 是一种可用于制造骨植入物的生物相容性材料。在这项工作中,PMMA、PMMA/HA、PMMA/Mg 和 PMMA/HA/Mg 支架的组合是通过冷冻铸造工艺制造的。研究了 PMMA 及其与 HA 和 Mg 的组合的孔径、孔隙率和抗压强度的变化。所有四种组合的孔径均大于 200 µm。这表明所有四种类型的支架在其生物学功能上都适用于骨植入物。PMMA/HA(26.08 MPa)支架的抗压强度高于松质骨。在这项工作中,