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Differentiating renal pelvic cancer from renal cell carcinoma with 18-fluorodeoxyglucose positron emission tomography-computed tomography
Journal of Cancer Research and Therapeutics ( IF 1.3 ) Pub Date : 2021-07-01 , DOI: 10.4103/jcrt.jcrt_217_16 Murat Dursun 1 , Emin Ozbek 2 , Alper Otunctemur 3 , Huseyin Besiroglu 3
Background: The differential diagnosis of pelvis renalis cancer (PRC) from renal cell cancer (RCC) is difficult. Because of that, in this study, we compared the standardized uptake value (SUV) with positron emission tomography-computed tomography (PET-CT) of the RCC and PRC.
Methods: Twenty-one patients (12 males, 9 females; age range: 33–74 years; mean age ± standard deviation [SD]: 57.14 ± 17.6) with suspected primary renal cell cancer as Group 1 and 8 patients (6 male, 2 female; age range, 61–81; mean age ± SD, 71.5 ± 5.65) with suspected renal pelvis cancer as Group 2 detected by conventional imaging techniques (CT, magnetic resonance [MR] imaging, ultrasound, intravenous urogram, CT urography, MR urography) underwent fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT imaging between August 2010 and October 2012.
Results: Mean age is 57.14 (33–74) years in Group 1 and 71.5 (61–81) years in Group 2, respectively. The mean maximum SUV (SUVmax) value was 4.6 ± 2.1 in RCC group and 16.6 ± 6.9 in PRC group. At the 18-FDG PET/CT scanning, SUVmax value higher in patients with PRC than in the patients with RCC. It was statistically different (P < 0.001).
Conclusion: We suggested that PET/CT can be used for the differential diagnosis of renal pelvis tumor and RCC. However, further studies with larger patient number are needed to confirm our suggestion. To clarify the mechanisms of underlying these differences, molecular advanced molecular studies are needed.
中文翻译：
18-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描鉴别肾盂癌和肾细胞癌
背景：肾盂肾癌（PRC）与肾细胞癌（RCC）的鉴别诊断很困难。因此，在本研究中，我们比较了 RCC 和 PRC 的标准化摄取值 (SUV) 与正电子发射断层扫描计算机断层扫描 (PET-CT)。
方法： 21 名疑似原发性肾细胞癌患者（12 名男性，9 名女性；年龄范围：33-74 岁；平均年龄 ± 标准差 [SD]：57.14 ± 17.6）作为第 1 组和 8 名患者（6 名男性， 2 名女性；年龄范围，61-81；平均年龄 ± SD，71.5 ± 5.65），疑似肾盂癌为第 2 组，通过常规成像技术（CT、磁共振 [MR] 成像、超声、静脉尿路造影、CT 尿路造影、 MR 尿路造影）接受氟-18-氟脱氧葡萄糖（18F-FDG）2010 年 8 月至 2012 年 10 月期间的 PET/CT 成像。
结果：第 1 组的平均年龄为 57.14（33-74）岁，第 2 组的平均年龄分别为 71.5（61-81）岁。RCC 组的平均最大 SUV (SUV max ) 值为 4.6 ± 2.1，PRC 组为 16.6 ± 6.9。在 18-FDG PET/CT 扫描中，PRC 患者的 SUV最大值高于 RCC 患者。差异有统计学意义（P < 0.001）。
结论：我们建议PET/CT可用于肾盂肿瘤和RCC的鉴别诊断。然而，需要更多患者数量的进一步研究来证实我们的建议。为了阐明这些差异的潜在机制，需要进行分子高级分子研究。
更新日期：2021-07-01
Journal of Cancer Research and Therapeutics ( IF 1.3 ) Pub Date : 2021-07-01 , DOI: 10.4103/jcrt.jcrt_217_16 Murat Dursun 1 , Emin Ozbek 2 , Alper Otunctemur 3 , Huseyin Besiroglu 3
Affiliation
Background: The differential diagnosis of pelvis renalis cancer (PRC) from renal cell cancer (RCC) is difficult. Because of that, in this study, we compared the standardized uptake value (SUV) with positron emission tomography-computed tomography (PET-CT) of the RCC and PRC.
Methods: Twenty-one patients (12 males, 9 females; age range: 33–74 years; mean age ± standard deviation [SD]: 57.14 ± 17.6) with suspected primary renal cell cancer as Group 1 and 8 patients (6 male, 2 female; age range, 61–81; mean age ± SD, 71.5 ± 5.65) with suspected renal pelvis cancer as Group 2 detected by conventional imaging techniques (CT, magnetic resonance [MR] imaging, ultrasound, intravenous urogram, CT urography, MR urography) underwent fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT imaging between August 2010 and October 2012.
Results: Mean age is 57.14 (33–74) years in Group 1 and 71.5 (61–81) years in Group 2, respectively. The mean maximum SUV (SUVmax) value was 4.6 ± 2.1 in RCC group and 16.6 ± 6.9 in PRC group. At the 18-FDG PET/CT scanning, SUVmax value higher in patients with PRC than in the patients with RCC. It was statistically different (P < 0.001).
Conclusion: We suggested that PET/CT can be used for the differential diagnosis of renal pelvis tumor and RCC. However, further studies with larger patient number are needed to confirm our suggestion. To clarify the mechanisms of underlying these differences, molecular advanced molecular studies are needed.
中文翻译：
18-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描鉴别肾盂癌和肾细胞癌
背景：肾盂肾癌（PRC）与肾细胞癌（RCC）的鉴别诊断很困难。因此，在本研究中，我们比较了 RCC 和 PRC 的标准化摄取值 (SUV) 与正电子发射断层扫描计算机断层扫描 (PET-CT)。
方法： 21 名疑似原发性肾细胞癌患者（12 名男性，9 名女性；年龄范围：33-74 岁；平均年龄 ± 标准差 [SD]：57.14 ± 17.6）作为第 1 组和 8 名患者（6 名男性， 2 名女性；年龄范围，61-81；平均年龄 ± SD，71.5 ± 5.65），疑似肾盂癌为第 2 组，通过常规成像技术（CT、磁共振 [MR] 成像、超声、静脉尿路造影、CT 尿路造影、 MR 尿路造影）接受氟-18-氟脱氧葡萄糖（18F-FDG）2010 年 8 月至 2012 年 10 月期间的 PET/CT 成像。
结果：第 1 组的平均年龄为 57.14（33-74）岁，第 2 组的平均年龄分别为 71.5（61-81）岁。RCC 组的平均最大 SUV (SUV max ) 值为 4.6 ± 2.1，PRC 组为 16.6 ± 6.9。在 18-FDG PET/CT 扫描中，PRC 患者的 SUV最大值高于 RCC 患者。差异有统计学意义（P < 0.001）。
结论：我们建议PET/CT可用于肾盂肿瘤和RCC的鉴别诊断。然而，需要更多患者数量的进一步研究来证实我们的建议。为了阐明这些差异的潜在机制，需要进行分子高级分子研究。
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