Introduction: Hematological inflammatory markers and metabolic parameters in positron-emission tomography/computed tomography (PET/CT) are important indicators predicting the prognosis of the disease in lung cancer as in many cancers. This study aimed to evaluate the correlation between pretreatment hematological inflammatory markers and PET/CT metabolic parameters in nonsmall cell lung cancer (NSCLC) patients and to predict the prognostic value of these parameters.
Materials and Methods: A total of 132 patients with diagnosed NSCLC who underwent PET/CT at staging were retrospectively evaluated. Hematological parameters were obtained from the hemogram taken no more than 2 weeks prior to PET/CT. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) were recorded. Maximum standard uptake value, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated. Clinical stage, tumor pathology, and overall survival were analyzed with these parameters.
Results: NLR and PLR were significantly positively correlated with MTV and TLG (all P < 0.001), MPV was negatively correlated with TLG (P = 0.021). While TLG, MTV, NLR, and PLR were increased in advanced stage disease, MPV was decreased. Univariate Cox-regression analysis demonstrated that greater age (P = 0.015), advanced stage (P < 0.001), low MPV (P = 0.017), high NLR (P < 0.001), PLR (P < 0.001), MTV (P = 0.004), TLG (P = 0.001) values, multivariate Cox-regression analysis revealed that NLR (P < 0.001) and advanced stage (P < 0.001) were significant predictors of poor prognosis in patients with NSCLC.
Conclusions: There were significant associations between hematological inflammatory markers and PET/CT metabolic parameters in the patients with NSCLC at the time of diagnosis. These indicators can contribute to predicting prognosis in patients with NSCLC.


中文翻译：

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18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描代谢参数的预后影响及其与肺癌血液炎症标志物的相关性


简介：正电子发射断层扫描/计算机断层扫描 (PET/CT) 中的血液炎症标志物和代谢参数是预测肺癌疾病预后的重要指标，与许多癌症一样。本研究旨在评估非小细胞肺癌 (NSCLC) 患者治疗前血液炎症标志物与 PET/CT 代谢参数之间的相关性，并预测这些参数的预后价值。
材料和方法：回顾性评估了 132 名在分期时接受 PET/CT 诊断的 NSCLC 患者。血液学参数从 PET/CT 前不超过 2 周拍摄的血象中获得。记录中性粒细胞与淋巴细胞的比率 (NLR)、血小板与淋巴细胞的比率 (PLR) 和平均血小板体积 (MPV)。计算最大标准摄取值、SUVmean、代谢肿瘤体积（MTV）和总病灶糖酵解（TLG）。使用这些参数分析临床分期、肿瘤病理学和总生存期。
结果： NLR、PLR与MTV、TLG呈显着正相关（均P < 0.001），MPV与TLG呈负相关（P= 0.021)。晚期疾病TLG、MTV、NLR和PLR升高，MPV降低。单变量 Cox 回归分析表明年龄较大 ( P = 0.015)、晚期 ( P < 0.001)、低 MPV ( P = 0.017)、高 NLR ( P < 0.001)、PLR ( P < 0.001)、MTV ( P = 0.004）、TLG（P =0.001）值、多变量Cox回归分析显示，NLR（P <0.001）和晚期（P <0.001）是NSCLC患者预后不良的重要预测因素。
结论：诊断时 NSCLC 患者的血液学炎症标志物与 PET/CT 代谢参数之间存在显着相关性。这些指标有助于预测 NSCLC 患者的预后。