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Role of AMH in Prediction of Menopause
Frontiers in Endocrinology ( IF 5.2 ) Pub Date : 2021-09-14 , DOI: 10.3389/fendo.2021.733731
Annelien C de Kat 1 , Frank J M Broekmans 1 , Cornelis B Lambalk 2
Affiliation  

Anti-Müllerian Hormone (AMH) is produced by small antral follicles and has evolved over the past three decades as an assumed potential marker of the number of follicles in the human ovaries, also known as ovarian reserve. This quantitative measure, given the gradual decline over time and its non-replenishable feature, could be the dreamed marker for predicting the final exhaustion of ovarian storage: the post-menopause. This introductory chapter summarizes current knowledge with regard to the contribution of serum AMH measurements to predict age of normal menopause and critically discuss its potential in this regard. Furthermore, its predictive role in the context of menopause in association with several frequently occurring fertility disorders such as premature menopause, polycystic ovarian syndrome and endometriosis are discussed. Overall, while ovarian reserve markers including AMH are unmistakably related to age at menopause, they are insufficiently precise to inform on an individual’s journey of ovarian aging.



中文翻译:

AMH 在预测更年期中的作用

抗苗勒管激素 (AMH) 由小窦卵泡产生,在过去的三十年中已经发展成为人类卵巢中卵泡数量的潜在潜在标志物,也称为卵巢储备。鉴于随着时间的推移逐渐下降及其不可补充的特征,这种定量测量可能是预测卵巢储存最终耗尽的梦想标志:绝经后。这一介绍性章节总结了当前关于血清 AMH 测量对预测正常绝经年龄的贡献的知识,并批判性地讨论了其在这方面的潜力。此外,还讨论了它在更年期与几种常见生育障碍相关的预测作用,如过早绝经、多囊卵巢综合征和子宫内膜异位症。全面的,

更新日期:2021-09-14
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