Frontiers in Cellular and Infection Microbiology ( IF 5.7 ) Pub Date : 2021-09-14 , DOI: 10.3389/fcimb.2021.744903 Rashmi Rana 1 , Ankit Tripathi 1 , Naveen Kumar 1 , Nirmal Kumar Ganguly 1
The outbreak of COVID-19 has proven to be an unprecedented disaster for the whole world. The virus has inflicted billion of lives across the globe in all aspects—physically, psychologically, as well as socially. Compared to the previous strains of β-CoV genera- MERS and SARS, SARS-CoV-2 has significantly higher transmissibility and worst post-recovery implications. A frequent mutation in the initial SARS-CoV-2 strain has been a major cause of mortalities (approx. 3 million deaths) and uncontrolled virulence (approx. 1 billion positive cases). As far as clinical manifestations are concerned, this particular virus has exhibited deleterious impacts on systems other than the respiratory system (primary target organ), such as the brain, hematological system, liver, kidneys, endocrine system, etc. with no promising curatives to date. Lack of emergency treatments and shortage of life-saving drugs has promoted the repurposing of existing therapeutics along with the emergence of vaccines with the combined efforts of scientists and industrial experts in this short span. This review summarizes every detail on COVID-19 and emphasizes undermining the future approaches to minimize its prevalence to the remaining lives.
中文翻译:
COVID-19 全面概述:未来展望
事实证明,COVID-19 的爆发对全世界来说是一场前所未有的灾难。该病毒在身体、心理和社交等各个方面给全球数十亿人带来了影响。与之前的 β-CoV 病毒株和 SARS 病毒株相比,SARS-CoV-2 具有明显更高的传播性和最严重的恢复后影响。最初的 SARS-CoV-2 病毒株的频繁突变是导致死亡(约 300 万人死亡)和毒力失控(约 10 亿阳性病例)的主要原因。就临床表现而言,这种特殊病毒对呼吸系统(主要靶器官)以外的系统,如大脑、血液系统、肝脏、肾脏、内分泌系统等都表现出有害影响,目前尚无有希望的治疗方法。日期。紧急治疗的缺乏和救生药物的短缺,在科学家和工业专家的共同努力下,随着疫苗的出现,在短时间内促进了现有疗法的重新利用。这篇评论总结了有关 COVID-19 的每一个细节,并强调破坏未来尽量减少其在剩余生命中流行的方法。