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Positional Information and Stem Cells Combine to Result in Planarian Regeneration
Cold Spring Harbor Perspectives in Biology ( IF 7.2 ) Pub Date : 2022-04-01 , DOI: 10.1101/cshperspect.a040717 Peter W Reddien 1, 2, 2
Cold Spring Harbor Perspectives in Biology ( IF 7.2 ) Pub Date : 2022-04-01 , DOI: 10.1101/cshperspect.a040717 Peter W Reddien 1, 2, 2
Affiliation
The capacity for regeneration is broad in the animal kingdom. Planarians are flatworms that can regenerate any missing body part and their regenerative powers have combined with ease of experimentation to make them a classic regeneration model for more than a century. Pluripotent stem cells called neoblasts generate missing planarian tissues. Fate specification happens in the neoblasts, and this can occur in response to regeneration instructions in the form of positional information. Fate specification can lead to differentiating cells in single steps rather than requiring a long lineage hierarchy. Planarians display constitutive expression of positional information from muscle cells, which is required for patterned maintenance of tissues in tissue turnover. Amputation leads to the rapid resetting of positional information in a process triggered by wound signaling and the resetting of positional information is required for regeneration. These findings suggest a model for planarian regeneration in which adult positional information resets after injury to regulate stem cells to bring about the replacement of missing parts.
中文翻译:
位置信息和干细胞结合导致涡虫再生
动物界的再生能力是广泛的。真涡虫是一种扁虫,可以再生任何缺失的身体部位,它们的再生能力与易于实验相结合,使它们成为一个多世纪以来的经典再生模型。称为新生细胞的多能干细胞产生缺失的涡虫组织。命运规范发生在新生细胞中,这可以响应位置信息形式的再生指令而发生。命运规范可以导致在单个步骤中区分细胞,而不需要长的谱系层次结构。涡虫显示来自肌肉细胞的位置信息的本构表达,这是组织更新中组织模式维持所必需的。截肢导致在伤口信号触发的过程中位置信息的快速重置,并且位置信息的重置是再生所必需的。这些发现提出了一种涡虫再生模型,其中成年涡虫的位置信息在受伤后重新设置以调节干细胞以替换缺失的部分。
更新日期:2022-04-01
中文翻译:
位置信息和干细胞结合导致涡虫再生
动物界的再生能力是广泛的。真涡虫是一种扁虫,可以再生任何缺失的身体部位,它们的再生能力与易于实验相结合,使它们成为一个多世纪以来的经典再生模型。称为新生细胞的多能干细胞产生缺失的涡虫组织。命运规范发生在新生细胞中,这可以响应位置信息形式的再生指令而发生。命运规范可以导致在单个步骤中区分细胞,而不需要长的谱系层次结构。涡虫显示来自肌肉细胞的位置信息的本构表达,这是组织更新中组织模式维持所必需的。截肢导致在伤口信号触发的过程中位置信息的快速重置,并且位置信息的重置是再生所必需的。这些发现提出了一种涡虫再生模型,其中成年涡虫的位置信息在受伤后重新设置以调节干细胞以替换缺失的部分。