The Cover Feature shows naturally occurring (2S,3S)- and (2S,3R)-tetrahydro-3-hydroxy-5-oxo-2,3-furan dicarboxylic acid bearing, chemically amenable functional groups that are an ideal choice for the enantiopure synthesis of the (−)- and (+)-Crispine A, respectively. The diastereomeric natural products are conveniently converted to desirable enantiomers of Crispine A through the chiral pool strategy. This exciting and efficient strategy is one of the well-explored trends in synthetic organic chemistry, especially regarding molecules procured from tropical plant material (Nature) and serves as key step in the enantiopure synthesis of small-molecule natural products. More information can be found in the Minireview by C. Mohan, I. Ibnusaud et al.

中文翻译：

---

封面特征：Pyrrolo[2,1-a]异喹啉类天然产物 Crispine A 的合成（Eur. J. Org. Chem. 35/2021）

封面特征显示自然发生的 (2 S ,3 S )- 和 (2 S ,3 R)-四氢-3-羟基-5-氧代-2,3-呋喃二羧酸，具有化学适应性的官能团，分别是 (-)- 和 (+)-Crispine A 的对映纯合成的理想选择。通过手性池策略，非对映天然产物可以方便地转化为 Crispine A 的理想对映异构体。这种令人兴奋且有效的策略是合成有机化学中已充分探索的趋势之一，特别是关于从热带植物材料（自然）采购的分子，并且是小分子天然产物对映体纯合成的关键步骤。更多信息可以在 C. Mohan、I. Ibnusaud 等人的 Minireview 中找到。