Evolution of multidrug resistance in Plasmodium falciparum: a longitudinal study of genetic resistance markers in the Greater Mekong Subregion,Antimicrobial Agents and Chemotherapy

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Evolution of multidrug resistance in Plasmodium falciparum: a longitudinal study of genetic resistance markers in the Greater Mekong Subregion
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-13 , DOI: 10.1128/aac.01121-21
Mallika Imwong _{1,

2} , Kanokon Suwannasin ₂ , Suttipat Srisutham ₃ , Ranitha Vongpromek ₄ , Cholrawee Promnarate ₄ , Aungkana Saejeng ₅ , Aung Pyae Phyo ₆ , Stephane Proux ₇ , Tiengkham Pongvongsa ₈ , Nguon Chea ₉ , Olivo Miotto _{2,

10,

11} , Rupam Tripura _{2,

11} , Chau Nguyen Hoang ₁₂ , Lek Dysoley ₉ , Nghia Ho Dang Trung ₁₂ , Thomas J Peto _{2,

11} , James J Callery ₂ , Rob W van der Pluijm ₂ , Chanaki Amaratunga _{2,

11} , Mavuto Mukaka _{2,

11} , Lorenz von Seidlein _{2,

11} , Mayfong Mayxay _{11,

13,

14} , Nguyen Thanh Thuy-Nhien ₁₂ , Paul N Newton ₁₁ , Nicholas P J Day _{2,

11} , Elizabeth A Ashley _{11,

14} , Francois H Nosten _{7,

11} , Frank M Smithuis _{6,

11} , Mehul Dhorda _{2,

3,

11} , Nicholas J White _{2,

11} , Arjen M Dondorp _{2,

11}

Affiliation

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Worldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Division of Vector-Borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
Myanmar Oxford Clinical Research Unit, Yangon, Myanmar.
Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Mae Sot, Thailand.
Savannakhet Provincial Health Department, Savannakhet, Lao People's Democratic Republic.
National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.
Wellcome Sanger Institute, Hinxton, United Kingdom.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Oxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Institute of Research and Education Development, University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospitalgrid.416302.2, Vientiane, Lao People's Democratic Republic.

Increasing drug resistance in Plasmodium falciparum to artemisinins and their ACT partner drugs jeopardises effective antimalarial treatment. Resistance is worst in the Greater Mekong Subregion. Monitoring genetic markers of resistance can help to guide ...

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