Species-specific differences in C-5 sterol desaturase function influence the outcome of azole antifungal exposure.,Antimicrobial Agents and Chemotherapy

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Species-specific differences in C-5 sterol desaturase function influence the outcome of azole antifungal exposure.
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-13 , DOI: 10.1128/aac.01044-21
Arturo Luna-Tapia ₁ , Josie E Parker ₂ , Steven L Kelly ₂ , Glen E Palmer ₃

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The azole antifungals inhibit sterol 14α-demethylase (S14DM), leading to depletion of cellular ergosterol and the synthesis of an aberrant sterol-diol that disrupts membrane function. In Candida albicans, sterol diol production is catalyzed by the C-5 ...

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