Efficient Inhibition of Hepatitis B Virus Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors During Infection,Antimicrobial Agents and Chemotherapy

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Efficient Inhibition of Hepatitis B Virus Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors During Infection
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-13 , DOI: 10.1128/aac.01460-21
Ranjit Chauhan ₁ , Qilan Li _{1,

2} , Molly E Woodson _{1,

2} , Makafui Gasonoo _{2,

3} , Marvin J Meyers _{2,

3} , John E Tavis _{1,

2,

4}

Affiliation

The Hepatitis B Virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug target. Here, we addressed three limitations to the current state of RNase H inhibitor development: i) Efficacy has been assessed only in transfected cell lines; ii)...

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