The clinical characteristics of patients with postoperative hypoparathyroidism who recover parathyroid function more than 12 months after surgery have not been studied. We aimed to evaluate whether the intensity of replacement therapy with calcium and calcitriol is related to the late recovery of parathyroid function. We compared the demographic, surgical, pathological, and analytical features of two groups of patients: cases, i. e., late recovery patients (those who recover parathyroid function>1 year after thyroidectomy, n=40), and controls, i. e., patients with permanent hypoparathyroidism (n=260). Replacement therapy with calcium and calcitriol was evaluated at discharge of surgery, 3–6 months, 12 months, and last visit. No significant differences were found in clinical, surgical, pathological, or analytical characteristics between cases and controls. The proportion of cases who required treatment with calcium plus calcitriol at 12 months was significantly lower than that found in controls (p<0.001). Furthermore, daily calcium and calcitriol doses in controls were significantly higher than those in cases at 3–6 months (p=0.014 and p=0.004, respectively) and at 12 months (p<0.001 and p=0.043, respectively). In several models of logistic regression analysis therapy with calcium and calcitriol at 12 months was negatively related to late recovery of parathyroid function. Although delayed recuperation of parathyroid function after total thyroidectomy is uncommon (13%), follow-up beyond 12 months is necessary in patients with postoperative hypoparathyroidism, especially in those whose needs of treatment with Ca and calcitriol are reducing over time.

中文翻译：

---

全甲状腺切除术后甲状旁腺功能的晚期恢复：病例对照研究

尚未研究术后 12 个月以上甲状旁腺功能恢复的术后甲状旁腺功能减退症患者的临床特征。我们旨在评估钙和骨化三醇替代疗法的强度是否与甲状旁腺功能的晚期恢复有关。我们比较了两组患者的人口统计学、手术、病理学和分析特征：病例，i。例如，晚期恢复患者（甲状腺切除术后恢复甲状旁腺功能> 1年的患者，n=40）和对照组，i。例如，患有永久性甲状旁腺功能减退症的患者（n=260）。在手术出院、3-6 个月、12 个月和最后一次就诊时评估钙和骨化三醇的替代治疗。在临床、手术、病理、或案例和对照之间的分析特征。在 12 个月时需要钙加骨化三醇治疗的病例比例显着低于对照组（p<0.001）。此外，对照组的每日钙和骨化三醇剂量显着高于 3-6 个月（分别为 p = 0.014 和 p = 0.004）和 12 个月（分别为 p <0.001 和 p = 0.043）的病例。在几个逻辑回归分析模型中，12 个月时用钙和骨化三醇治疗与甲状旁腺功能的晚期恢复呈负相关。尽管全甲状腺切除术后甲状旁腺功能延迟恢复并不常见（13%），但术后甲状旁腺功能减退症患者需要随访超过 12 个月，