Aims To examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia. Methods Our analysis included 12 364 adults aged 55–73 years from the UK Biobank cohort. Participants were assessed between 2006 and 2010 at baseline and were followed up until the early of 2021. Incident dementia was ascertained using hospital inpatient, death records and self-reported data. Results Over 1 263 513 person-years of follow-up, 2304 cases of incident dementia were documented. The multivariable-adjusted HRs (95% CI) for dementia associated with age-related macular degeneration (AMD), cataract, diabetes-related eye disease (DRED) and glaucoma at baseline were 1.26 (1.05 to 1.52), 1.11 (1.00 to 1.24), 1.61 (1.30 to 2.00) and (1.07 (0.92 to 1.25), respectively. Diabetes, heart disease, stroke and depression at baseline were all associated with an increased risk of dementia. Of the combination of AMD and a systemic condition, AMD-diabetes was associated with the highest risk for incident dementia (HR (95% CI): 2.73 (1.79 to 4.17)). Individuals with cataract and a systemic condition were 1.19–2.29 times more likely to develop dementia compared with those without cataract and systemic conditions. The corresponding number for DRED and a systemic condition was 1.50–3.24. Diabetes, hypertension, heart disease, depression and stroke newly identified during follow-up mediated the association between cataract and incident dementia as well as the association between DRED and incident dementia. Conclusions AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only. Data are available in a public, open access repository. Data are available in a public, open access repository ().

中文翻译：

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英国生物库中眼科和全身疾病与痴呆事件的关联

目的 检查眼科和全身状况与痴呆事件的独立和交互关联。方法 我们的分析包括来自英国生物样本库队列的 12 364 名年龄在 55-73 岁之间的成年人。在 2006 年至 2010 年间对参与者进行了基线评估，并进行了随访，直至 2021 年初。使用住院病人、死亡记录和自我报告数据确定了痴呆症事件。结果 在超过 1 263 513 人年的随访中，记录了 2304 例痴呆事件。基线时与年龄相关性黄斑变性 (AMD)、白内障、糖尿病相关眼病 (DRED) 和青光眼相关的痴呆的多变量调整 HR (95% CI) 为 1.26（1.05 至 1.52）、1.11（1.00 至 1.24） ), 1.61 (1.30 to 2.00) 和 (1.07 (0.92 to 1.25), 分别。糖尿病、心脏病、基线时的中风和抑郁症都与痴呆症风险增加有关。在 AMD 和全身性疾病的组合中，AMD 糖尿病与痴呆症的风险最高相关（HR（95% CI）：2.73（1.79 至 4.17））。与没有白内障和全身性疾病的人相比，患有白内障和全身性疾病的人患痴呆症的可能性高 1.19-2.29 倍。DRED 和全身状况的相应数字为 1.50–3.24。随访期间新发现的糖尿病、高血压、心脏病、抑郁症和中风介导了白内障与痴呆事件之间的关联以及 DRED 与痴呆事件之间的关联。结论 AMD、白内障和 DRED 而不是青光眼与痴呆风险增加相关。与仅患有眼科或全身疾病的人相比，同时患有眼科和全身疾病的人患痴呆症的风险更高。数据可在公共、开放访问的存储库中获得。数据可在公共、开放访问的存储库中获取（).