Abstract

Although Alexander Spirin was most known for his ribosome work, his earlier research on RNA synthesis during vertebrate embryogenesis was also pioneering. There he introduced the idea that messenger RNA exists as a complex with proteins. He named these particles “informosomes”, mainly for the RNA species they contained but also hinting that this ribonucleoprotein form might underlie control of the mRNA’s translation. Although the notion that mRNA is complexed with proteins was entirely plausible and had considerable supporting data, it was received with skepticism in some quarters. Here I briefly summarize this phase of Spirin’s early work and offer my perspectives and speculations on why its acceptance was unduly delayed.

中文翻译：

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信息体，东方和​​西方

摘要

尽管亚历山大·斯皮林以其核糖体工作而闻名，但他早期对脊椎动物胚胎发生过程中 RNA 合成的研究也是开创性的。在那里，他介绍了信使 RNA 作为蛋白质复合物存在的想法。他将这些颗粒命名为“信息体”，主要是因为它们包含的 RNA 种类，但也暗示这种核糖核蛋白形式可能是 mRNA 翻译控制的基础。尽管 mRNA 与蛋白质复合的观点是完全合理的，并且有大量的支持数据，但在某些方面受到了怀疑。在这里，我简要总结了 Spirin 早期工作的这一阶段，并就其接受被过度延迟的原因提出了我的观点和推测。