Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials.

中文翻译：

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BNT162b2 信使核糖核酸冠状病毒病 2019 (COVID-19) 疫苗接种后 COVID-19-Naive 疗养院居民的细胞和体液免疫反应动态

在未接触过 COVID-19 的疗养院居民中接种 BNT162b2 信使核糖核酸冠状病毒病 2019 (COVID-19) 疫苗后，短期体液和细胞免疫反应减弱，该人群特别容易感染该病。我们发现这两种反应都在 4 周后下降，并且在 24 周后仍低于医护人员的反应，估计抗体反应的半衰期为 47 天。在 4 周时，年龄较大与体液反应降低显着相关，糖尿病和活动性恶性肿瘤与细胞反应降低相关。我们的结果表明，未接触过 COVID-19 的疗养院居民是加强疫苗接种试验的目标群体。