The phospholipases A2 (PLA2) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA2s has analyzed their roles in inflammation, anti-bacterial actions, and atherosclerosis. In recent studies utilizing a variety of mouse models, pancreatic islets, and clinical trials, a role for many of these enzymes in the control of metabolism and insulin action has been revealed. In this review, this research, and the unique contributions of the PLA2 enzymes in insulin resistance and metabolism.

中文翻译：

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胰岛素抵抗和代谢中的分泌型磷脂酶 A2s。

磷脂酶 A2 (PLA2) 超家族包括哺乳动物组织和蛇毒中常见的酶。许多这些酶具有独特的组织分布、功能和底物特异性，表明了不同的生物学作用。过去，许多关于分泌型 PLA2 的研究都分析了它们在炎症、抗菌作用和动脉粥样硬化中的作用。在最近利用各种小鼠模型、胰岛和临床试验的研究中，已经揭示了许多这些酶在控制代谢和胰岛素作用中的作用。在这篇综述中，这项研究以及 PLA2 酶在胰岛素抵抗和代谢中的独特贡献。