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Analysis of Predictive Risk Factors in Aquaporin-4-IgG Positive Highly Active Neuromyelitis Optica Spectrum Disorders.
Frontiers in Neurology ( IF 3.4 ) Pub Date : 2021-08-26 , DOI: 10.3389/fneur.2021.731835 Yanfei Li 1 , Jinwei Zhang 1 , Yongyan Zhou 1 , Haojie Xie 1 , Ranran Duan 1 , Lijun Jing 1 , Yaobing Yao 1 , Junfang Teng 1 , Yanjie Jia 1
Frontiers in Neurology ( IF 3.4 ) Pub Date : 2021-08-26 , DOI: 10.3389/fneur.2021.731835 Yanfei Li 1 , Jinwei Zhang 1 , Yongyan Zhou 1 , Haojie Xie 1 , Ranran Duan 1 , Lijun Jing 1 , Yaobing Yao 1 , Junfang Teng 1 , Yanjie Jia 1
Affiliation
Neuromyelitis optica spectrum disorders (NMOSDs) are inflammatory diseases with a high risk of recurrence and progressive disability, and it is crucial to find sensitive and reliable biomarkers for prognosis and the early prediction of relapse. Highly active NMOSD is defined as two or more clinical relapses within a 12-month period. In this study, we analyzed independent risk factors among patients with aquaporin-4 (AQP4)-IgG positive highly active NMOSD. In this retrospective study, we analyzed the data of 94 AQP4-IgG positive patients with highly active NMOSD and 105 AQP4-IgG positive controls with non-highly active NMOSD. In order to rule out possible effects of previous treatments (such as glucocorticoids, immunoglobulin, and immunosuppressants), we focused on the first-attack NMOSD patients admitted to our hospital. Clinical data, including the age of onset, gender, comorbidities, and serum analysis and cerebrospinal fluid (CSF) analysis results, were collected, after which logistic regression models were used to determine the associations between the clinical factors and relapse outcomes. The prevalence of connective tissue disease and the proportion of antinuclear antibody (ANA)-positivity were higher in the highly active NMOSD group than in the control group. The leukocyte counts, homocysteine (Hcy) levels, CSF leukocyte counts, protein concentrations, IgG indexes, and 24h IgG synthesis rates were also higher in the highly active NMOSD group. The results of multivariate analysis indicated that connective tissue disease comorbidity (OR = 5.953, 95% CI: 1.221-29.034, P = 0.027), Hcy levels (OR = 1.063, 95% CI: 1.003-1.126, P = 0.04), and 24h IgG synthesis rate (OR = 1.038, 95% CI: 1.003-1.075, P = 0.034) may be independent risk factors for AQP4-IgG positive highly active NMOSD relapse after adjusting for various variables. Comorbidity of connective tissue disease, Hcy levels, and 24h IgG synthesis rate may be independent risk factors for AQP4-IgG positive highly active NMOSD.
中文翻译:
Aquaporin-4-IgG 阳性高活性视神经脊髓炎谱系疾病的预测危险因素分析。
视神经脊髓炎谱系疾病(NMOSDs)是一种具有高复发风险和进行性残疾的炎症性疾病,寻找灵敏可靠的生物标志物用于预后和早期预测复发至关重要。高度活跃的 NMOSD 被定义为 12 个月内两次或两次以上的临床复发。在本研究中,我们分析了水通道蛋白 4 (AQP4)-IgG 阳性高活性 NMOSD 患者的独立危险因素。在这项回顾性研究中,我们分析了 94 名具有高活性 NMOSD 的 AQP4-IgG 阳性患者和 105 名具有非高活性 NMOSD 的 AQP4-IgG 阳性对照的数据。为了排除既往治疗(如糖皮质激素、免疫球蛋白和免疫抑制剂)的可能影响,我们重点研究了我院收治的初发 NMOSD 患者。临床数据,收集包括发病年龄、性别、合并症、血清分析和脑脊液(CSF)分析结果在内的数据,然后使用逻辑回归模型确定临床因素与复发结果之间的关联。高活性NMOSD组结缔组织病患病率和抗核抗体(ANA)阳性比例高于对照组。高活性 NMOSD 组的白细胞计数、同型半胱氨酸 (Hcy) 水平、脑脊液白细胞计数、蛋白质浓度、IgG 指数和 24 小时 IgG 合成率也较高。多变量分析结果表明结缔组织病合并症(OR = 5.953, 95% CI: 1.221-29.034, P = 0.027)、Hcy水平(OR = 1.063, 95% CI: 1.003-1.126, P = 0.04) 24h IgG 合成率 (OR = 1.038, 95% CI:1.003-1.075,P = 0.034)可能是调整各种变量后 AQP4-IgG 阳性高活性 NMOSD 复发的独立危险因素。结缔组织病合并症、Hcy 水平和 24h IgG 合成率可能是 AQP4-IgG 阳性高活性 NMOSD 的独立危险因素。
更新日期:2021-08-26
中文翻译:
Aquaporin-4-IgG 阳性高活性视神经脊髓炎谱系疾病的预测危险因素分析。
视神经脊髓炎谱系疾病(NMOSDs)是一种具有高复发风险和进行性残疾的炎症性疾病,寻找灵敏可靠的生物标志物用于预后和早期预测复发至关重要。高度活跃的 NMOSD 被定义为 12 个月内两次或两次以上的临床复发。在本研究中,我们分析了水通道蛋白 4 (AQP4)-IgG 阳性高活性 NMOSD 患者的独立危险因素。在这项回顾性研究中,我们分析了 94 名具有高活性 NMOSD 的 AQP4-IgG 阳性患者和 105 名具有非高活性 NMOSD 的 AQP4-IgG 阳性对照的数据。为了排除既往治疗(如糖皮质激素、免疫球蛋白和免疫抑制剂)的可能影响,我们重点研究了我院收治的初发 NMOSD 患者。临床数据,收集包括发病年龄、性别、合并症、血清分析和脑脊液(CSF)分析结果在内的数据,然后使用逻辑回归模型确定临床因素与复发结果之间的关联。高活性NMOSD组结缔组织病患病率和抗核抗体(ANA)阳性比例高于对照组。高活性 NMOSD 组的白细胞计数、同型半胱氨酸 (Hcy) 水平、脑脊液白细胞计数、蛋白质浓度、IgG 指数和 24 小时 IgG 合成率也较高。多变量分析结果表明结缔组织病合并症(OR = 5.953, 95% CI: 1.221-29.034, P = 0.027)、Hcy水平(OR = 1.063, 95% CI: 1.003-1.126, P = 0.04) 24h IgG 合成率 (OR = 1.038, 95% CI:1.003-1.075,P = 0.034)可能是调整各种变量后 AQP4-IgG 阳性高活性 NMOSD 复发的独立危险因素。结缔组织病合并症、Hcy 水平和 24h IgG 合成率可能是 AQP4-IgG 阳性高活性 NMOSD 的独立危险因素。