As an important medium of intercellular communication, exosomes play an important role in information transmission between tumor cells and their microenvironment. Tumor metastasis is a serious influencing factor for poor treatment effect and shortened survival. Lung cancer is a major malignant tumor that seriously threatens human health. The study of the underlying mechanisms of exosomes in tumor genesis and development may provide new ideas for early and effective diagnosis and treatment of lung cancer metastasis. Many studies have shown that tumor-derived exosomes promote lung cancer development through a number of processes. By promoting epithelial–mesenchymal transition of tumor cells, they induce angiogenesis, establishment of the pretransfer microenvironment, and immune escape. This understanding enables researchers to better understand the mechanism of lung cancer metastasis and explore new treatments for clinical application. In this article, we systematically review current research progress of tumor-derived exosomes in metastasis of lung cancer. Although positive progress has been made toward understanding the mechanism of exosomes in lung cancer metastasis, systematic basic research and clinical translational research remains lacking and are needed to translate our scientific understanding toward applications in the clinical diagnosis and treatment of lung cancer metastasis in the near future.

中文翻译：

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肿瘤相关外泌体通过多种机制促进肺癌转移

作为细胞间通讯的重要媒介，外泌体在肿瘤细胞与其微环境之间的信息传递中发挥着重要作用。肿瘤转移是治疗效果差、生存期缩短的严重影响因素。肺癌是严重威胁人类健康的重大恶性肿瘤。研究外泌体在肿瘤发生发展中的潜在机制，可能为肺癌转移的早期有效诊治提供新思路。许多研究表明，肿瘤衍生的外泌体通过许多过程促进肺癌的发展。通过促进肿瘤细胞的上皮-间质转化，它们诱导血管生成、转移前微环境的建立和免疫逃逸。这种认识使研究人员能够更好地了解肺癌转移的机制，并探索临床应用的新疗法。本文系统综述了肿瘤源性外泌体在肺癌转移中的研究进展。尽管在了解外泌体在肺癌转移中的作用机制方面取得了积极进展，但仍缺乏系统的基础研究和临床转化研究，需要将我们的科学认识转化为在不久的将来应用于肺癌转移的临床诊断和治疗。 .