Previously, the simultaneous presence of endocarditis (IE) has been reported in 3–30% of spondylodiscitis cases. The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82 ± 4.12 years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE n = 13/36 vs. S n = 57/292, p < 0.05 and chronic heart failure n = 11/36 vs. S n = 41/292, p < 0.05, chronic renal failure SIE n = 14/36 vs. S n = 55/292, p < 0.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S = 4.5 ± 4.5 days vs. SIE = 8.9 ± 9.5 days, p < 0.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.

此前，据报道在 3-30% 的脊椎间盘炎病例中同时存在心内膜炎 (IE)。两种疾病同时存在对治疗和结果的具体影响尚未得到充分评估。因此，本研究的目的是调查同时存在的心内膜炎对脊椎间盘炎治疗过程和结果的影响。使用倾向评分匹配的统计分析对 328 名诊断为自发性脊椎间盘炎 (S) 的患者进行前瞻性数据库分析。36 名患者 (11.0%) 通过经食道超声心动图诊断为并发心内膜炎 (SIE)。在我们的队列中，平均年龄为 65.82 ± 4.12 岁，64.9% 的患者为男性。n  = 13/36 vs. S n  = 57/292, p  < 0.05 和慢性心力衰竭n  = 11/36 vs. S n  = 41/292, p  < 0.05, 慢性肾功能衰竭 SIE n  = 14/36 vs. S n  = 55/292，p  < 0.05）。复杂的跨学科协调和诊断导致手术干预显着延迟（S = 4.5 ± 4.5 天 vs. SIE = 8.9 ± 9.5 天，p < 0.05)。死亡率没有显示出统计学上的显着差异：S (13.4%) 和 SIE (19.1%)。诊断和治疗的时间是有效治疗和患者安全的关键。为了抵消延迟治疗，我们基于对 SIE 组治疗过程的分析开发了一种新的治疗算法。我们提出了一个明确的治疗途径，以避免经常观察到的陷阱和诊断延误，从而改善患者护理和结果。