ABSTRACT

Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells and adipose tissue inflammation, with a focus on regulation by T cell subtypes. Studies have shown that Th1, Th17 and CD8⁺ T cells, which are important T cell subsets, can promote the development of adipose tissue inflammation, whereas Treg cells protect against inflammation, suggesting that targeting the mechanism by which T cell subtypes regulate adipose tissue inflammation is a potential therapeutic strategy for treating obesity. T cells play important roles in regulating obesity-associated adipose tissue inflammation, thus providing new research directions for the treatment of obesity. More studies are needed to clarify how T cell subtypes regulate adipose tissue inflammation to identify new treatments for obesity.

摘要

肥胖患者的脂肪组织炎症可引起一系列代谢性疾病。脂肪组织中存在多种免疫细胞，研究表明T细胞与脂肪组织炎症有关。本综述旨在描述目前对 T 细胞与脂肪组织炎症之间关系的理解，重点关注 T 细胞亚型的调节。研究表明，重要的T细胞亚群Th1、Th17和CD8 ⁺ T细胞可以促进脂肪组织炎症的发展，而Treg细胞则具有抗炎症作用，这表明针对T细胞亚型调节脂肪组织炎症的机制是治疗肥胖症的潜在治疗策略。T细胞在调节肥胖相关脂肪组织炎症中发挥重要作用，从而为肥胖的治疗提供新的研究方向。需要更多的研究来阐明 T 细胞亚型如何调节脂肪组织炎症，从而找到治疗肥胖的新疗法。