Emerging findings provide compelling evidence that the BRCA1-binding partner BARD1 contributes yet further to BRCA1 function. BARD1 is crucial for positioning the E2 ubiquitin-conjugating enzyme that confers specificity of its ligase to residues on histone H2A, and BARD1 also promotes DNA damage–induced chromatin recruitment through an interaction with ubiquitin-conjugated Lys13 or Lys15 of H2A on the nucleosome core particle.

中文翻译：

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是包裹吗？BRCA1 结合伙伴 BARD1 的核小体相互作用窃取现场

新发现提供了令人信服的证据，表明 BRCA1 结合伙伴 BARD1 进一步促进 BRCA1 功能。BARD1 对于定位 E2 泛素结合酶至关重要，该酶赋予其连接酶对组蛋白 H2A 上残基的特异性，并且 BARD1 还通过与核小体核心颗粒上 H2A 的泛素结合 Lys13 或 Lys15 相互作用促进 DNA 损伤诱导的染色质募集.