Background

Exposure to higher levels of outdoor air pollution is associated with increased morbidity in individuals with cystic fibrosis. Limited information exist regarding the potential adverse effects of indoor air pollution on those with cystic fibrosis.

Methods

Individuals with cystic fibrosis who were enrolled in the Twin and Sibling Study from 2000-2013, self-reported exposure to four known sources of indoor air pollution (secondhand smoke, forced hot air, wood stove and fireplace). Change in lung function, rates of hospitalizations and pulmonary exacerbations were followed over 4 years to compare outcomes in those who were exposed to those who were not exposed.

Results

Of 1432 participants with data on secondhand smoke exposure, 362 (25.3%) were exposed. Of 765 individuals with data on forced hot air exposure, 491 (64.2%) were exposed. Of 1247 participants with data on wood stove exposure and 830 with data on fireplace exposure, 182 (14.6%) and 373 (44.9%) were exposed, respectively. In longitudinal analysis, pediatric individuals either exposed to secondhand smoke or to forced hot air had a 0.60% predicted/year decrease in FEV₁% predicted (P=0.002) or a 0.46% predicted/year decrease in FEV1% predicted (P=0.048), respectively compared to individuals who were not exposed. Adults exposed to secondhand smoke had a 42% increased yearly risk of hospitalization compared to those who were not exposed (P=0.045).

Conclusions

Our questionnaire-based data suggest that exposure to sources of indoor air pollution increase morbidity in both the pediatric and adult cystic fibrosis populations. Future studies with quantitative indoor air quality assessments are needed.

中文翻译：

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室内空气污染暴露与囊性纤维化的发病率更高有关

背景

暴露于较高水平的室外空气污染与囊性纤维化患者的发病率增加有关。关于室内空气污染对囊性纤维化患者的潜在不利影响的信息有限。

方法

在 2000 年至 2013 年期间参加双胞胎和兄弟姐妹研究的囊性纤维化患者自我报告暴露于四种已知的室内空气污染源（二手烟、强制热风、柴火炉和壁炉）。对肺功能的变化、住院率和肺部恶化进行了 4 年多的跟踪，以比较暴露于未暴露者的结果。

结果

在有二手烟暴露数据的 1432 名参与者中，有 362 名 (25.3%) 被暴露。在有强制热空气暴露数据的 765 人中，有 491 人 (64.2%) 被暴露。在 1247 名有柴炉暴露数据的参与者和 830 名有壁炉暴露数据的参与者中，分别有 182 名 (14.6%) 和 373 名 (44.9%) 暴露。_{在纵向分析中，暴露于二手烟或强制热空气的儿科个体FEV1}预测值每年减少 0.60% （P=0.002）或 FEV1% 预测值每年减少 0.46%（P=0.048） )，分别与未暴露的个体相比。与未接触二手烟的成年人相比，接触二手烟的成年人每年住院风险增加 42% (P=0.045)。

结论

我们基于问卷的数据表明，接触室内空气污染源会增加儿童和成人囊性纤维化人群的发病率。需要进行定量室内空气质量评估的未来研究。