Visualizing acid-base equilibria and determining acid-base equilibrium constants (pK_a) in aqueous to the non-aqueous medium is essential for understanding the various chemical and biochemical processes. This mini review highlights the possibility of fine-tuning the traditional acid-base indicator dye‘s physicochemical properties into ionic liquids (ILs)-integrated ones to enhance their solubility and practical applications in a wide range of solvents. These include the high sensitivity towards acid and bases by virtue of its colour and spectral properties changes. ILs-based indicators could be used to determine the pK_a values in aqueous to the non-aqueous medium from polar to non-polar ones by overlapping indicator method. This review provides an essential idea of the emerging challenges and openings that may motivate the scientific communities to move towards IL-integrated acid-base indicators and find their dissociation constants (pK_Ind) in any solvents depending on their solubility. The calculated pK_Ind values could be used to determine the pK_a values of different acids and bases in any solvents. It would also be beneficial to find a general trend of acidity and basicity from solvents to solvents using such types of indicators without alternating the main moiety. It will benefit the scientific communities to understand the pK_a scales in different solvents.

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用于水至非水介质的基于离子液体的酸碱指示剂：概述

可视化酸碱平衡并确定水介质到非水介质中的酸碱平衡常数 (p K _a ) 对于理解各种化学和生化过程至关重要。这篇简短的评论强调了将传统酸碱指示剂染料的物理化学特性微调到离子液体 (IL) 集成的特性中的可能性，以提高它们在各种溶剂中的溶解度和实际应用。这些包括由于其颜色和光谱特性的变化而对酸和碱的高度敏感性。基于 ILs 的指标可用于确定 p K _a用重叠指示剂法测定水相至非水介质中极性至非极性的数值。这篇综述提供了关于新出现的挑战和开放的基本思想，这些挑战和开放可能会促使科学界转向集成 IL 的酸碱指示剂，并根据它们的溶解度在任何溶剂中找到它们的解离常数 (p K _Ind )。计算出的 p K _Ind值可用于确定任何溶剂中不同酸和碱的 p K _a值。使用这种类型的指示剂而不交替主要部分来发现从溶剂到溶剂的酸度和碱度的一般趋势也将是有益的。它将有利于科学界了解 pK _a在不同溶剂中缩放。