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Hispano-American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders
Brain Pathology ( IF 6.4 ) Pub Date : 2021-09-13 , DOI: 10.1111/bpa.13019
Brett D Dufour 1, 2 , Lilia Albores-Gallo 3 , Jose Luna-Muñoz 4 , Randi Hagerman 5, 6 , Amaya Miquelajauregui 7 , Efrain Buriticá 8 , Wilmar Saldarriaga 9 , Mar Pacheco-Herrero 10 , Ana Yris Silvestre-Sosa 11 , Carla Mazefsky 12 , Holly Gastgeb 12 , Julia Kofler 13 , Manuel Casanova 14 , Patrick R Hof 15 , Eric London 16 , Paul Hagerman 6, 17 , Verónica Martínez-Cerdeño 1, 2, 6
Affiliation  

Neurodevelopmental disorders (NDDs) are conditions that present with brain dysfunction due to alterations in the processes of brain development. They present with neuropsychiatric, cognitive, and motor symptoms. Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are two of the most common NDDs. Human brain tissue is a scarce resource that is obtained from postmortem donations. In the case of NDDs, specifically autism, the reduced donation rate of brains prevents researchers to investigate its pathology and fine anatomy. The Hispano-American Brain Bank of Neurodevelopmental Disorders (Banco Hispanoamericano de CErebros de trastornos del NEurodesarrollo) or CENE is a large-scale brain bank for neurodevelopmental disorders in Hispano-America and the US. CENE's objectives are to collect and distribute brains of patients with NDDS, with a focus on ASD and FXS, to perform research, promote education of future scientists, and enhance public awareness about the importance of human tissue availability for scientific research on brain function and disease. CENE has thus far established a bilingual system of nodes and teams in several American countries including California-US, Pennsylvania-US, México, Puerto Rico, Colombia, and Dominican Republic. CENE ensures that postmortem NDD samples used in research better match the world's genetic and ethnic diversity. CENE enables and expands NDD brain research worldwide, particularly with respect to ASD and FXS.

中文翻译:

Hispano-American Brain Bank on Neurodevelopmental Disorders:一项促进神经发育障碍领域脑库、研究、教育和外展的倡议

神经发育障碍 (NDD) 是由于大脑发育过程的改变而导致大脑功能障碍的病症。他们表现出神经精神、认知和运动症状。自闭症谱系障碍 (ASD) 和脆性 X 综合征 (FXS) 是两种最常见的 NDD。人脑组织是从死后捐赠中获得的稀缺资源。对于 NDD,特别是自闭症,大脑捐赠率的降低阻碍了研究人员调查其病理学和精细解剖学。西班牙裔美国人神经发育障碍脑库 (Banco Hispanoamericano de CE rebros de trastornos del NEurodesarrollo) 或 CENE 是西班牙裔美洲和美国的一个大型神经发育障碍脑库。CENE 的目标是收集和分发 NDDS 患者的大脑,重点是 ASD 和 FXS,以进行研究,促进未来科学家的教育,并提高公众对人体组织可用性对大脑功能和疾病科学研究的重要性的认识. CENE迄今已在美国加州、美国宾夕法尼亚州、墨西哥、波多黎各、哥伦比亚、多米尼加共和国等多个美国国家建立了节点和团队的双语体系。CENE 确保研究中使用的尸检 NDD 样本更好地匹配世界的遗传和种族多样性。CENE 在全球范围内启用并扩展了 NDD 大脑研究,特别是在 ASD 和 FXS 方面。
更新日期:2021-09-13
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