The ability to engineer custom-made medical devices and to implant them minimally invasively are two important trends in modern surgery. The personalization of the device is achieved by 3D printing it, while the capacity to deploy it minimally invasively harnesses the shape memory behavior displayed by the inks used. This study introduces a 3D printed, shape memory-displaying tracheal stent based on novel, flexible photo-polymerizable inks comprising polypropylene glycol/polycaprolactone triblocks. This research introduces the in situ welding strategy, whereby thin and flexible layers of the stent are separately printed, sequentially deployed, and then welded together at the tracheal site. By doing so, the insertion profile of the device is dramatically reduced and its flexibility largely increased. Porous stents are 3D printed seeking to prevent mucus plugging. By combining more than one ink, their properties are further fine-tuned. Polyethylene glycol chains are covalently bonded to the stent surface to minimize biofilm formation, an important drawback of current tracheal stents. The in vitro cell viability and cell adhesion behavior of the treated surfaces reveal their compatibility and anti-adhesive behavior. In order to prevent implant-related infections, ciprofloxacin is added to the ink, and released in vitro over time, rendering the stent with antibacterial activity.

中文翻译：

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个性化多功能 3D 打印形状记忆显示、释药气管支架

设计定制医疗设备并以微创方式植入它们的能力是现代外科手术的两个重要趋势。该设备的个性化是通过 3D 打印实现的，而微创部署它的能力则利用所用墨水显示的形状记忆行为。本研究介绍了一种 3D 打印的、显示形状记忆的气管支架，该支架基​​于包含聚丙二醇/聚己内酯三嵌段的新型柔性光聚合油墨。这项研究介绍了原位焊接策略，即支架的薄而灵活的层被单独打印，顺序部署，然后在气管部位焊接在一起。通过这样做，设备的插入轮廓显着减少，其灵活性大大增加。多孔支架是 3D 打印的，旨在防止粘液堵塞。通过组合一种以上的墨水，它们的属性得到进一步微调。聚乙二醇链与支架表面共价结合，以最大限度地减少生物膜的形成，这是当前气管支架的一个重要缺点。处理过的表面的体外细胞活力和细胞粘附行为揭示了它们的相容性和抗粘附行为。为了防止与植入物相关的感染，将环丙沙星添加到墨水中，并随着时间的推移在体外释放，使支架具有抗菌活性。处理过的表面的体外细胞活力和细胞粘附行为揭示了它们的相容性和抗粘附行为。为了防止与植入物相关的感染，将环丙沙星添加到墨水中，并随着时间的推移在体外释放，使支架具有抗菌活性。处理过的表面的体外细胞活力和细胞粘附行为揭示了它们的相容性和抗粘附行为。为了防止与植入物相关的感染，将环丙沙星添加到墨水中，并随着时间的推移在体外释放，使支架具有抗菌活性。