In both artificial electronic and ionic skins, the distinction of multi-stimuli response in a single sensing unit is challenging, due to unavoidable mutual signal interference. Here, a zwitterionic skin sensor system that can continuously monitor and differentiate three-stimuli-responsive information in real-time is designed. This sandwich-structured sensor system is based on a zwitterionic thermo–glucose-sensitive skin-like hydrogel at its upper and lower layers with a middle isolation elastomer layer, enabling monitoring and distinction of temperature, mechanical and glucose information without signal interference: 1) the capacitance of the upper/lower layers as glucose–temperature-insensitive is variable to measure strain; 2) the resistance of the upper hydrogel as glucose-insensitive is variable to measure strain and temperature; and 3) the resistance of the lower hydrogel can detect three indicators. Based on the skin sensor system, a smart wound dressing is developed to pro-heal chronic diabetic wounds and enable continuous real-time monitoring of three indicators—infection, swelling, and blood glucose. This work provides a new method of real-time monitoring and the distinction of multi-stimuli response in a wearable device.

中文翻译：

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Pro-Healing 两性离子皮肤传感器可实现多指标区分和连续实时监测

在人造电子和离子皮肤中，由于不可避免的相互信号干扰，在单个传感单元中区分多刺激响应是具有挑战性的。在这里，设计了一种两性离子皮肤传感器系统，可以实时连续监测和区分三刺激响应信息。这种夹心结构的传感器系统基于两性离子热-葡萄糖敏感皮肤状水凝胶，其上下层具有中间隔离弹性体层，能够在没有信号干扰的情况下监测和区分温度、机械和葡萄糖信息：1)上/下层的电容作为葡萄糖-温度不敏感是可变的以测量应变；2) 上部水凝胶的电阻作为葡萄糖不敏感是可变的以测量应变和温度；3）下层水凝胶的电阻可以检测三个指标。基于皮肤传感器系统，开发了一种智能伤口敷料，以促进慢性糖尿病伤口的愈合，并能够连续实时监测感染、肿胀和血糖三个指标。这项工作为可穿戴设备中的实时监测和多刺激响应的区分提供了一种新方法。