During implantation, the murine embryo transitions from a “quiet” into an active metabolic/proliferative state, which kick-starts the growth and morphogenesis of the post-implantation conceptus. Such transition is also required for embryonic stem cells to be established from mouse blastocysts, but the factors regulating this process are poorly understood. Here, we show that Ronin plays a critical role in the process by enabling active energy production, and the loss of Ronin results in the establishment of a reversible quiescent state in which naïve pluripotency is promoted. In addition, Ronin fine-tunes the expression of genes that encode ribosomal proteins and is required for proper tissue-scale organisation of the pluripotent lineage during the transition from blastocyst to egg cylinder stage. Thus, Ronin function is essential for governing the metabolic capacity so that it can support the pluripotent lineage’s high-energy demands for cell proliferation and morphogenesis.

中文翻译：

---

Ronin 控制着胚胎谱系在植入后发育中的代谢能力

在植入过程中，小鼠胚胎从“安静”状态转变为活跃的代谢/增殖状态，从而启动植入后胎体的生长和形态发生。从小鼠胚泡中建立胚胎干细胞也需要这种转变，但调节这一过程的因素知之甚少。在这里，我们表明 Ronin 通过实现主动能量产生在该过程中发挥关键作用，而 Ronin 的损失导致建立可逆的静止状态，在这种状态下促进幼稚的多能性。此外，Ronin 可以微调编码核糖体蛋白的基因的表达，并且在从囊胚到卵圆柱阶段的过渡过程中，多能谱系的适当组织规模组织是必需的。因此，