This study reports a fluorescence iron core-carbonized biocompatible hybrid poly(ethylene glycol) (PEG)-oriented nanogel (Fe₂O₃@C@PEG-COOH nanogel). The fluorescence Fe₂O₃@C@PEG-COOH nanogel is prepared using a facile one-pot polycondensation reaction without organic solvents or catalysts. The properties of the fluorescenceFe₂O₃@C@PEG-COOH nanogel are investigated by fluorescence spectroscopy, transmission electron microscopy, X-ray diffraction, and thermogravimetric analysis. A change in pH as a stimulus can trigger the release of loaded doxorubicin (DOX). Under acidic conditions, the nanogel releases the highly loaded drug slowly compared to the neutral and basic conditions, which is important for cancer treatment. The synthesized fluorescenceFe₂O₃@C@PEG-COOH nanogel is well dispersed in water and shows fluorescence with high photostability, good biocompatibility with a paramagnetic nature. Furthermore, the nanogel can act as a potential fluorescent probe for cell imaging.

中文翻译：

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用于细胞内成像和控制药物释放的 pH 响应生物相容性荧光核壳纳米凝胶

本研究报告了一种荧光铁核-碳化生物相容性混合聚（乙二醇）（PEG）取向的纳米凝胶（Fe ₂ O ₃ @C@PEG-COOH 纳米凝胶）。荧光 Fe ₂ O ₃ @C@PEG-COOH 纳米凝胶使用简便的一锅缩聚反应制备，无需有机溶剂或催化剂。Fe ₂ O ₃的荧光性质@C@PEG-COOH 纳米凝胶通过荧光光谱、透射电子显微镜、X 射线衍射和热重分析进行研究。作为刺激物的 pH 值变化可触发加载的多柔比星 (DOX) 的释放。在酸性条件下，与中性和碱性条件相比，纳米凝胶缓慢释放高负载药物，这对癌症治疗很重要。合成的荧光Fe ₂ O ₃ @C@PEG-COOH纳米凝胶在水中分散良好，具有高光稳定性、良好的生物相容性和顺磁性的荧光。此外，纳米凝胶可以作为细胞成像的潜在荧光探针。