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Investigation of solvent microparticle formation in spray ionization–quadrupole ion trap–mass spectrometry
Journal of Mass Spectrometry ( IF 2.3 ) Pub Date : 2021-09-13 , DOI: 10.1002/jms.4785
Abdil Özdemir, Jung-Lee Lin, Mustafa Gülfen, Chung-Hsuan Chen

In the present study, a new method has been developed for the real-time analysis of insource created solvent particles based on spray ionization–quadrupole ion trap–mass spectrometry (SI-QIT-MS). This is the first work in the literature reporting the formation of different solvent particles during solvent spray in mass spectrometry. The solvent particles formed from the solvent droplets are detected by a charge detector. Our ion trap system allows the measurement of a wide range particle masses. Various solvents and solvent mixtures such as water, methanol, acetone, toluene, n-butanol, water-methanol, and water-ethanol were sprayed through a cone system, and the mass of the particles was monitored by different trap frequencies and voltages. While polar molecules produce larger and more diverse particles due to their strong intermolecular forces, apolar solvents generally do not produce a significant number of particles. We obtained results using a homemade ion trap mass spectrometer capable of determining the mass of micro-sized solvent and solvent mixture particles weighing up to 1015 (Da). The instrument uses a charge detector connected to the exit of the ion trap. Simultaneous acquisition of particle mass spectra and measurement of the amount of charge in each particle allow mass assignment of each particle. Sprayed solvent particles were examined at various trap frequencies and voltages to find the best instrumental parameters for the highest trapping efficiency. The custom SI-QIT-MS instrument allows the measurement of the mass distribution of charged particles from the solvent spray.

中文翻译:

喷雾电离-四极杆离子阱-质谱法中溶剂微粒形成的研究

在本研究中,开发了一种基于喷雾电离-四极杆离子阱-质谱 (SI-QIT-MS) 实时分析源内产生的溶剂颗粒的新方法。这是文献中首次报道了质谱中溶剂喷雾过程中不同溶剂颗粒的形成。由溶剂液滴形成的溶剂颗粒由电荷检测器检测。我们的离子阱系统可以测量大范围的粒子质量。将水、甲醇、丙酮、甲苯、正丁醇、水-甲醇和水-乙醇等各种溶剂和溶剂混合物通过锥形系统喷洒,并通过不同的陷阱频率和电压监测颗粒的质量。虽然极性分子由于其强大的分子间作用力产生更大和更多样化的粒子,非极性溶剂通常不会产生大量颗粒。我们使用自制的离子阱质谱仪获得了结果,该质谱仪能够确定重达 1015 (大)。该仪器使用连接到离子阱出口的电荷检测器。粒子质谱的同时采集和每个粒子中电荷量的测量允许每个粒子的质量分配。在各种捕集频率和电压下检查喷洒的溶剂颗粒,以找到最高捕集效率的最佳仪器参数。定制的 SI-QIT-MS 仪器允许测量来自溶剂喷雾的带电粒子的质量分布。
更新日期:2021-10-06
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