For achieving early intervention treatment to help patients delay or avoid joint replacement surgery, a personalized scaffold should be designed coupling the effects of mechanical, fluid mechanical, chemical, and biological factors on tissue regeneration, which results in time- and cost-consuming trial-and-error analyses to investigate the in vivo test and related experimental tests. To optimize the fluid mechanical and material properties to predict osteogenesis and cartilage regeneration for the in vivo and clinical trial, a simulation approach is developed for scaffold design, which is composed of a volume of a fluid model for simulating the bone marrow filling process of the bone marrow and air, as well as a discrete phase model and a cell impingement model for tracking cell movement during bone marrow fillings. The bone marrow is treated as a non-Newtonian fluid, rather than a Newtonian fluid, because of its viscoelastic property. The simulation results indicated that the biofunctional bionic scaffold with a dense layer to prevent the bone marrow flow to the cartilage layer and synovia to flow into the trabecular bone area guarantee good osteogenesis and cartilage regeneration, which leads to high-accuracy in vivo tests in sheep . This approach not only predicts the final bioperformance of the scaffold but also could optimize the scaffold structure and materials by their biochemical, biological, and biomechanical properties.

为了实现早期干预治疗以帮助患者延迟或避免关节置换手术，应设计个性化的支架，将机械、流体机械、化学和生物因素对组织再生的影响相结合，从而导致耗时且耗时的试验-和误差分析来调查 体内测试和相关的实验测试。优化流体力学和材料特性，以预测骨生成和软骨再生体内和临床试验，开发了支架设计的模拟方法，该方法由用于模拟骨髓和空气的骨髓填充过程的流体模型的体积，以及用于模拟骨髓和空气的离散相模型和细胞撞击模型组成。跟踪骨髓填充过程中的细胞运动。由于其粘弹性，骨髓被视为非牛顿流体，而不是牛顿流体。模拟结果表明，具有致密层的生物功能仿生支架可防止骨髓流向软骨层和滑膜流入骨小梁区域，保证了良好的成骨和软骨再生，从而实现了高精度体内在绵羊中进行测试。这种方法不仅可以预测支架的最终生物性能，还可以通过其生化、生物学和生物力学特性优化支架结构和材料。