The increased level of pesticide residues in vegetables is a potential threat to human health, especially in children. In this study, human health risk assessment associated with the presence of pesticide residues in fresh pointed gourd (Trichosanthes dioica Roxb.) samples purchased from different markets of Dhaka City, Bangladesh, was done. Six selected organophosphorus pesticide residues (dimethoate, fenitrothion, chlorpyrifos, quinalphos, diazinon and malathion) in the samples were determined using modified QuEChERS extraction and gas chromatography coupled with flame thermionic detector. The method was validated by assessing the accuracy, precision, linearity, limit of detection (LOD) and limit of quantification (LOQ). The average recoveries of the selected pesticides ranged from 85 to 106% with precision in case of repeatability ≤ 10% and combined uncertainty < 7 % in five fortification levels of 0.01 mg kg⁻¹, 0.05 mg kg⁻¹, 0.1 mg kg⁻¹, 0.2 mg kg⁻¹ and 0.3 mg kg⁻¹. The linearity of the calibration curve was very good and the relative residuals were < 20 %. The LOD ranged from 0.002 mg kg⁻¹ to 0.003 mg kg⁻¹ and the LOQ was determined at 0.01 mg kg⁻¹ for all the selected analytes. This method was applied successfully for the residue analysis of fresh pointed gourd samples. Among the analyzed samples, 8 (11.43 %) had pesticide residues, of which none had multiple pesticide residues. All of the contaminated samples contained residue above European Union-Maximum Residue Levels. Out of the eight contaminated samples, health risk was exceeded the acceptable value (< 1) in five for adults and seven for children associated with the residues of chlorpyrifos, quinalphos, diazinon and dimethoate. This finding reveals the public health concern due to potential of pesticide toxicity in vegetables for the consumers. Therefore, continuous monitoring on the use of pesticides in vegetables should be strengthened.

蔬菜中农药残留量的增加对人类健康构成潜在威胁，尤其是儿童。在本研究中，与新鲜尖头葫芦（Trichosanthes dioica Roxb）中农药残留的存在相关的人类健康风险评估.) 从孟加拉国达卡市不同市场购买的样品已完成。使用改进的 QuEChERS 萃取和气相色谱结合火焰热离子检测器测定了样品中六种选定的有机磷农药残留（乐果、杀螟硫磷、毒死蜱、喹诺磷、二嗪农和马拉硫磷）。该方法通过评估准确度、精密度、线性、检测限 (LOD) 和定量限 (LOQ) 进行验证。在 0.01 mg kg ^-1、0.05 mg kg ^-1、0.1 mg kg ^-1五个加标水平下，所选农药的平均回收率在 85% 至 106% 的范围内，在重复性≤ 10% 且组合不确定度< 7 % 的情况下具有精确度, 0.2 mg kg ^-1和 0.3 mg kg ^-1. 校准曲线的线性非常好，相对残差 < 20%。LOD 范围为 0.002 mg kg ^-1至 0.003 mg kg ^-1，LOQ 为 0.01 mg kg ^-1对于所有选定的分析物。该方法已成功应用于新鲜尖头葫芦样品的残留分析。在分析的样品中，有8份（11.43%）含有农药残留，其中没有一份含有多种农药残留。所有受污染的样品都含有高于欧盟最高残留水平的残留物。在 8 个受污染样本中，有 5 个成人和 7 个儿童的健康风险超过了可接受值（< 1），与毒死蜱、喹硫磷、二嗪农和乐果的残留有关。这一发现揭示了消费者对蔬菜中农药毒性的潜在影响。因此，应加强对蔬菜中农药使用的持续监测。