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Distribution of monocytes subpopulations in the peripheral blood from patients with Behçet's disease - Impact of disease status and colchicine use
Clinical Immunology ( IF 8.6 ) Pub Date : 2021-09-13 , DOI: 10.1016/j.clim.2021.108854
Talita C Gazzito Del Padre 1 , Joice Moraes F M Belem 1 , Mariana Freitas de Aguiar 1 , Heron Fernandes Vieira Torquato 2 , Edgar Julian Paredes-Gamero 3 , Wayel H Abdulahad 4 , Elisabeth Brouwer 4 , Alexandre W S de Souza 1
Affiliation  

The innate immune response has a predominant role in Behçet's disease (BD) pathogenesis, but few studies have assessed monocytes in BD. This study aims to evaluate the profile of monocytes subsets in the peripheral blood of BD patients and healthy controls (HC). Monocytes subsets were identified as classical (CD14+CD16), intermediate (CD14+CD16dim), and non-classical (CD14dimCD16high) subsets. Patients with BD presented a lower number of total monocytes (p = 0.020) and a lower number (p < 0.0001) of circulating classical monocytes than HC. In contrast, the number of intermediate monocytes was higher in BD patients than HC (p < 0.0001). In BD patients, no associations were observed with the severity of clinical manifestations or therapy. Colchicine was associated with a higher number of non-classical monocytes (p = 0.035). In conclusion, BD patients present an altered distribution of monocytes subsets with a reduction of classical and an increase of intermediate subsets.



中文翻译:

白塞氏病患者外周血中单核细胞亚群的分布 - 疾病状态和秋水仙碱使用的影响

先天免疫反应在白塞病 (BD) 发病机制中起主要作用,但很少有研究评估 BD 中的单核细胞。本研究旨在评估 BD 患者和健康对照 (HC) 外周血中单核细胞亚群的特征。单核细胞亚群被确定为经典(CD14 + CD16 -)、中间(CD14 + CD16 dim)和非经典(CD14 dim CD16 high)亚群。与 HC 相比,BD 患者的总单核细胞数量 ( p  = 0.020) 和循环经典单核细胞数量较少 ( p < 0.0001)。相比之下,BD 患者的中间单核细胞数量高于 HC(p  < 0.0001)。在 BD 患者中,未观察到与临床表现或治疗的严重程度相关联。秋水仙碱与更多数量的非经典单核细胞相关 ( p  = 0.035)。总之,BD 患者表现出单核细胞亚群分布的改变,经典亚群减少,中间亚群增加。

更新日期:2021-09-16
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