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An elegant and efficient synthesis of heterocycles integrated with bis-N-acyl pyrazoline and bis-1, 2, 3-triazole via a green synthetic methodology
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2021-09-12 , DOI: 10.1002/jhet.4362
Archana Vellingiri 1 , Dinesh Murugan 1 , George Gnana Kumar 1 , Ponnuswamy Alagusundaram 1
Affiliation  

Highly efficient and sustainable one-pot multicomponent synthetic protocol has been accomplished for the synthesis of novel bis-N-substituted pyrazolinyl-1, 2, 3-triazole hybrids from readily available starting materials via operationally simple mechanochemical grinding approach. The present solvent-free synthetic protocol is advantageous for being atom economic involving short reaction time, ambient temperature, and non-chromatographic separation of products.

中文翻译:

通过绿色合成方法优雅高效地合成与双-N-酰基吡唑啉和双-1, 2, 3-三唑相结合的杂环

高效和可持续的一釜合成的多组分协议已经完成了新颖的合成- ñ -取代吡唑啉基,1,2,通过操作简单机械化学研磨方法从容易得到的起始原料1,2,3-三唑的杂种。目前的无溶剂合成方案有利于原子经济,包括反应时间短、环境温度和产品的非色谱分离。
更新日期:2021-09-12
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