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SynWiki: Functional annotation of the first artificial organism Mycoplasma mycoides JCVI-syn3A
Protein Science ( IF 8 ) Pub Date : 2021-09-13 , DOI: 10.1002/pro.4179
Tiago Pedreira 1 , Christoph Elfmann 1 , Neil Singh 1 , Jörg Stülke 1
Affiliation  

The new field of synthetic biology aims at the creation of artificially designed organisms. A major breakthrough in the field was the generation of the artificial synthetic organism Mycoplasma mycoides JCVI-syn3A. This bacterium possesses only 452 protein-coding genes, the smallest number for any organism that is viable independent of a host cell. However, about one third of the proteins have no known function indicating major gaps in our understanding of simple living cells. To facilitate the investigation of the components of this minimal bacterium, we have generated the database SynWiki (http://synwiki.uni-goettingen.de/). SynWiki is based on a relational database and gives access to published information about the genes and proteins of M. mycoides JCVI-syn3A. To gain a better understanding of the functions of the genes and proteins of the artificial bacteria, protein–protein interactions that may provide clues for the protein functions are included in an interactive manner. SynWiki is an important tool for the synthetic biology community that will support the comprehensive understanding of a minimal cell as well as the functional annotation of so far uncharacterized proteins.

中文翻译:

SynWiki:第一个人工有机体 Mycoplasma mycoides JCVI-syn3A 的功能注释

合成生物学的新领域旨在创造人工设计的生物。该领域的一个重大突破是人工合成生物Mycoplasma mycoides JCVI-syn3A 的产生。这种细菌仅拥有 452 个蛋白质编码基因,这是任何独立于宿主细胞存活的生物体中数量最少的。然而,大约三分之一的蛋白质没有已知的功能,这表明我们对简单活细胞的理解存在重大差距。为了便于研究这种最小细菌的成分,我们生成了数据库Syn Wiki (http://synwiki.uni-goettingen.de/)。Syn Wiki 基于一个关系数据库,可以访问关于基因和蛋白质的已发表信息。蕈状支原体JCVI-syn3A。为了更好地了解人工细菌的基因和蛋白质的功能,以交互方式包含了可能为蛋白质功能提供线索的蛋白质-蛋白质相互作用。Syn Wiki 是合成生物学界的一个重要工具,它将支持对最小细胞的全面理解以及迄今为止未表征的蛋白质的功能注释。
更新日期:2021-09-13
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