Myeloid/lymphoid neoplasm with t(8;22)(p11.2;q11.2)/BCR-FGFR1 is an extremely rare diagnosis, with few reported cases to date. In contrast to other FGFR1-partner rearrangements that are associated with chronic eosinophilic leukemia, acute myeloid leukemia, and/or lymphoblastic lymphoma, patients with BCR-FGFR1 have a myeloproliferative disorder that closely resembles chronic myeloid leukemia (CML). The current report describes a rare case of a 61 year old man with an atypical CML phenotype associated with t(8;22)(p11.2;q11.2)/BCR-FGFR1. A literature review is presented to enhance the awareness of this rare diagnostic entity.

具有 t(8;22)(p11.2;q11.2)/ BCR-FGFR1 的髓系/淋巴肿瘤 是一种极其罕见的诊断，迄今为止报道的病例很少。与其他与慢性嗜酸性粒细胞白血病、急性髓系白血病和/或淋巴母细胞淋巴瘤相关的FGFR1-伴侣重排相反，BCR-FGFR1患者患有与 慢性粒细胞白血病 (CML) 非常相似的骨髓增殖性疾病。本报告描述了一个罕见的 61 岁男性病例，其具有与 t(8;22)(p11.2;q11.2)/ BCR-FGFR1相关的非典型 CML 表型。提供文献综述以提高对这种罕见诊断实体的认识。