The antifungal effect of diglyceryl dicaprylate, one of the emulsifiers used as a food additive, on Candida albicans that is a pathogenic fungus that is predominant in the oral cavity was investigated. This component did not affect C. albicans growth; however, it suppressed some virulence factors in a concentration-dependent manner. Furthermore, the suppression of pathogenic factors, such as biofilm formation, adhesion, highly pathogenic dimorphism, and ability to produce proteolytic enzymes, was due to reduction in mRNA expression levels of genes involved in fungal pathogenicities. From these results, this emulsifier could potentially prevent the development of intraoral and extraoral diseases involving C. albicans and could potentially use in oral care and improvement of quality of life.

中文翻译：

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二辛酸二甘油酯对白色念珠菌生长和致病性的影响。

研究了用作食品添加剂的乳化剂之一的二辛酸二甘油酯对口腔中占主导地位的致病性真菌白色念珠菌的抗真菌作用。该成分不影响白色念珠菌的生长；然而，它以浓度依赖性方式抑制了一些毒力因子。此外，致病因素的抑制，如生物膜形成、粘附、高致病性二态性和产生蛋白水解酶的能力，是由于与真菌致病性有关的基因的 mRNA 表达水平降低。从这些结果来看，这种乳化剂可以潜在地预防涉及白色念珠菌的口内和口外疾病的发展，并可能用于口腔护理和改善生活质量。