Ocean acidification (OA), which refers to a gradual decrease in seawater pH due to the absorption of atmospheric carbon dioxide, profoundly affects the growth, development and survival of bivalves. Relatively limited studies have assessed the resilience of bivalve to OA. In the present study, Patinopecten yessoensis, an economically and ecologically significant species, were exposed to low pH (pH = 7.5) for 4 weeks. Forty-seven scallops that died in the first week were considered pH-sensitive population, and 20 that were alive at the end of the experiment were considered pH-tolerant population. A genome-wide association study was conducted to identify the genomic loci associated the resilience of P. yessoensis to OA. Twenty-one single nucleotide polymorphisms were significantly associated with resilience, which were distributed in 11 linkage groups. Within the linkage disequilibrium block region (± 300 kb) surrounding the 21 SNPs, 193 candidate genes were successfully identified. Particularly, five associated SNPs were directly located on five genes, including SP24, CFDH, 5HTR3, HSDL1 and ZFP346. The GO enrichment and KEGG pathway analyses showed that the molecular response of P. yessoensis to OA mainly involved neural signal transmission, energy metabolism and redox reaction. Candidate genes were expressed during larval development and in adult tissues. Furthermore, the expression of 30 candidate genes changed significantly under low pH stress in the mantle. Our results reveal certain SNPs and candidate genes that could elucidate the different responses of P. yessoensis to OA. The genetic variations indicated molecular resilience in P. yessoensis populations, which may enable adaptation to future acidification stress.

海洋酸化（OA）是指由于吸收大气中的二氧化碳而导致海水pH值逐渐降低，深刻地影响着双壳贝类的生长、发育和生存。相对有限的研究评估了双壳类对 OA 的抵抗力。在本研究中，Patinopecten yessoensis是一种具有经济和生态意义的物种，被暴露在低 pH 值（pH = 7.5）下 4 周。在第一周死亡的 47 只扇贝被认为是 pH 敏感群体，而在实验结束时还活着的 20 只被认为是 pH 耐受群体。进行了全基因组关联研究以确定与P. yessoensis恢复力相关的基因组位点到OA。21个单核苷酸多态性与复原力显着相关，分布在11个连锁群中。在围绕 21 个 SNP 的连锁不平衡区（± 300 kb）内，成功鉴定了 193 个候选基因。特别是，五个相关的SNP直接位于五个基因上，包括SP24、CFDH、5HTR3、HSDL1和ZFP346。GO 富集和 KEGG 通路分析表明，P. yessoensis的分子反应OA主要涉及神经信号传递、能量代谢和氧化还原反应。候选基因在幼虫发育和成体组织中表达。此外，在地幔的低 pH 胁迫下，30 个候选基因的表达发生了显着变化。我们的结果揭示了某些 SNP 和候选基因，可以阐明P. yessoensis对 OA 的不同反应。遗传变异表明P. yessoensis种群的分子弹性，这可能使适应未来的酸化压力。