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Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2021-09-12 , DOI: 10.1111/jfbc.13917
Sun Young Park 1 , Hana Jung 2 , Zhaoyan Lin 1 , Keum Taek Hwang 1, 3 , Ho-Kyung Kwak 4
Affiliation  

A continuous high-fat/high-fructose diet induces inflammation and lowers vascular endothelial function in the body. This research examined the effects of black raspberry (BR) powder consumption on the inflammatory response and endothelial dysfunction in rats fed with a high-fat diet and fructose solution. Wistar rats were randomly divided into two groups as control (AIN-93G diet + distilled water) and HFF (high-fat diet + 20% fructose solution) groups, for 16 weeks. At 8 weeks, the HFF was further divided into three subgroups: HFF, HFFBR2.5 (2.5% BR in high-fat diet), and HFFBR5 (5% BR in high-fat diet). The BR-fed groups showed significantly higher high-density lipoprotein-cholesterol and lower triglycerides than the HFF group. Rats supplemented with BR showed decreased mRNA and protein expressions of inflammatory cytokines and adhesion molecules in the liver and aorta tissues. Furthermore, the aortic protein expression of endothelial nitroxide synthase was significantly greater in the HFFBR2.5 and HFFBR5 than HFF.

中文翻译:

黑树莓 (Rubus occidentalis) 可减轻 Wistar 大鼠的炎症标志物和血管内皮功能障碍,该大鼠用果糖溶液喂养高脂肪饮食

持续的高脂肪/高果糖饮食会诱发炎症并降低体内血管内皮功能。这项研究检查了黑树莓 (BR) 粉摄入对高脂肪饮食和果糖溶液喂养的大鼠炎症反应和内皮功能障碍的影响。Wistar大鼠随机分为对照组(AIN-93G饮食+蒸馏水)和HFF(高脂饮食+20%果糖溶液)两组,为期16周。在第 8 周时,HFF 进一步分为三个亚组:HFF、HFFBR2.5(高脂肪饮食中 2.5% BR)和 HFFBR5(高脂肪饮食中 5% BR)。与 HFF 组相比,BR 喂养组显示出显着更高的高密度脂蛋白胆固醇和更低的甘油三酯。补充BR的大鼠肝脏和主动脉组织中炎性细胞因子和粘附分子的mRNA和蛋白质表达降低。此外,HFFBR2.5 和 HFFBR5 中内皮氮氧化物合酶的主动脉蛋白表达显着高于 HFF。
更新日期:2021-10-06
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