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Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-10 , DOI: 10.3233/jad-210360
Sanne Kuipers 1 , Geert Jan Biessels 1 , Jacoba P Greving 2 , Raquel P Amier 3 , Jeroen de Bresser 4 , Esther E Bron 5 , Wiesje M van der Flier 6, 7 , Rob J van der Geest 4 , Astrid M Hooghiemstra 6 , Robert J van Oostenbrugge 8 , Matthias J P van Osch 4 , L Jaap Kappelle 1 , Lieza G Exalto 1 ,
Affiliation  

Background:Emerging evidence shows sex differences in manifestations of vascular brain injury in memory clinic patients. We hypothesize that this is explained by sex differences in cardiovascular function. Objective:To assess the relation between sex and manifestations of vascular brain injury in patients with cognitive complaints, in interaction with cardiovascular function. Methods:160 outpatient clinic patients (68.8±8.5 years, 38% female) with cognitive complaints and vascular brain injury from the Heart-Brain Connection study underwent a standardized work-up, including heart-brain MRI. We calculated sex differences in vascular brain injury (lacunar infarcts, non-lacunar infarcts, white matter hyperintensities [WMHs], and microbleeds) and cardiovascular function (arterial stiffness, cardiac index, left ventricular [LV] mass index, LV mass-to-volume ratio and cerebral blood flow). In separate regression models, we analyzed the interaction effect between sex and cardiovascular function markers on manifestations of vascular brain injury with interaction terms (sex*cardiovascular function marker). Results:Males had more infarcts, whereas females tended to have larger WMH-volumes. Males had higher LV mass indexes and LV mass-to-volume ratios and lower CBF values compared to females. Yet, we found no interaction effect between sex and individual cardiovascular function markers in relation to the different manifestations of vascular brain injury (p-values interaction terms > 0.05). Conclusion:Manifestations of vascular brain injury in patients with cognitive complaints differed by sex. There was no interaction between sex and cardiovascular function, warranting further studies to explain the observed sex differences in injury patterns.

中文翻译:

认知主诉患者血管性脑损伤的性别和心血管功能

背景:新出现的证据表明,记忆门诊患者血管性脑损伤表现存在性别差异。我们假设这是通过心血管功能的性别差异来解释的。目的:评估性别与认知障碍患者血管性脑损伤表现之间的关系,并与心血管功能相互作用。方法:来自心脑连接研究的 160 名患有认知障碍和血管性脑损伤的门诊患者(68.8±8.5 岁,38% 女性)接受了标准化的检查,包括心脑 MRI。我们计算了血管性脑损伤(腔隙性梗塞、非腔隙性梗塞、白质高信号 [WMH] 和微出血)和心血管功能(动脉僵硬、心脏指数、左心室 [LV] 质量指数、LV 质量体积比和脑血流量)。在单独的回归模型中,我们用交互项(性别*心血管功能标记)分析了性别和心血管功能标志物对血管性脑损伤表现的交互作用。结果:男性有更多的梗塞,而女性往往有更大的 WMH 体积。与女性相比,男性具有更高的 LV 质量指数和 LV 质量体积比和更低的 CBF 值。然而,我们发现性别和个体心血管功能标志物与血管性脑损伤的不同表现之间没有交互作用(p 值交互项 > 0.05)。结论:认知主诉患者血管性脑损伤的表现因性别而异。性别与心血管功能之间没有相互作用,
更新日期:2021-09-12
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