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Metabolomic Alterations in the Blood and Brain in Association with Alzheimer’s Disease: Evidence from in vivo to Clinical Studies
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-09 , DOI: 10.3233/jad-210737
Sirawit Sriwichaiin 1, 2, 3 , Nipon Chattipakorn 1, 2, 3 , Siriporn C Chattipakorn 1, 2, 3, 4
Affiliation  

Alzheimer’s disease (AD) has become a major health problem among the elderly population. Some evidence suggests that metabolic disturbance possibly plays a role in the pathophysiology of AD. Currently, the study of metabolomics has been used to explore changes in multiple metabolites in several diseases, including AD. Thus, the metabolomics research in AD might provide some information regarding metabolic dysregulations, and their possible associated pathophysiology. This review summarizes the information discovered regarding the metabolites in the brain and the blood from the metabolomics research of AD from both animal and clinical studies. Additionally, the correlation between the changes in metabolites and outcomes, such as pathological findings in the brain and cognitive impairment are discussed. We also deliberate on the findings of cohort studies, demonstrating the alterations in metabolites before changes of cognitive function. All of these findings can be used to inform the potential identity of specific metabolites as possible biomarkers for AD.

中文翻译:

血液和大脑中与阿尔茨海默病相关的代谢组学变化:来自体内至临床研究的证据

阿尔茨海默病 (AD) 已成为老年人群中的主要健康问题。一些证据表明代谢紊乱可能在 AD 的病理生理学中起作用。目前,代谢组学研究已被用于探索多种疾病(包括 AD)中多种代谢物的变化。因此,AD 的代谢组学研究可能会提供一些有关代谢失调及其可能相关病理生理学的信息。本综述总结了从动物和临床研究中发现的关于 AD 代谢组学研究中大脑和血液中代谢物的信息。此外,还讨论了代谢物变化与结果之间的相关性,例如大脑中的病理发现和认知障碍。我们还考虑了队列研究的结果,证明了认知功能改变之前代谢物的改变。所有这些发现都可用于告知特定代谢物作为 AD 可能的生物标志物的潜在身份。
更新日期:2021-09-12
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