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The Association of Periodontitis and Alzheimer’s Disease: How to Hit Two Birds with One Stone
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-08 , DOI: 10.3233/jad-210491
Tom Werber 1 , Zsofia Bata 2 , Eniko Szabo Vaszine 2 , Dalida Borbala Berente 1, 3 , Anita Kamondi 3, 4 , Andras Attila Horvath 3, 5
Affiliation  

Alzheimer’s disease (AD) is the leading cause of cognitive impairment in the elderly. Recent evidence suggests that preventive interventional trials could significantly reduce the risk for development of dementia. Periodontitis is the most common dental disease characterized by chronic inflammationand loss of alveolar bone and perialveolar attachment of teeth. Growing number of studies propose a potential link between periodontitis and neurodegeneration. In the first part of the paper, we overview case-control studies analyzing the prevalence of periodontitis among AD patients and healthy controls. Second, we survey observational libraries and cross-sectional studies investigating the risk of cognitive decline in patients with periodontitis. Next, we describe the current view on the mechanism of periodontitis linked neural damage, highlighting bacterial invasion of neural tissue from dental plaques, and periodontitis induced systemic inflammation resulting in a neuroinflammatory process. Later, we summarize reports connecting the four most common periodontal pathogens to AD pathology. Finally, we provide a practical guide for further prevalence and interventional studies on the management of cognitively high-risk patients with and without periodontitis. In this section, we highlight strategies for risk control, patient information, dental evaluation, reporting protocol and dental procedures in the clinical management of patients with a risk for periodontitis and with diagnosed periodontitis. In conclusion, our review summarizes the current view on the association between AD and periodontitis and provides a research and intervention strategy for harmonized interventional trials and for further case-control or cross-sectional studies.

中文翻译:

牙周炎与阿尔茨海默病的关联:如何用一颗石头打两只鸟

突出了牙菌斑对神经组织的细菌入侵,以及牙周炎引起的全身炎症,导致神经炎症过程。稍后,我们总结了将四种最常见的牙周病原体与 AD 病理联系起来的报告。最后,我们为有或没有牙周炎的认知高危患者的进一步流行和干预研究提供了实用指南。在本节中,我们重点介绍了风险控制、患者信息、牙科评估、报告协议和牙科程序在有牙周炎风险和诊断出牙周炎患者的临床管理中的策略。综上所述,
更新日期:2021-09-12
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