The quest for new functional nanomaterials is one of the defining purposes of nanoscience and nanotechnology. A large number of metal nanoparticles (NPs) are extensively exploited for biomedical applications. Metal NPs, in particular platinum NPs (PtNPs), possess remarkable properties that make them a potential candidate as a diagnostic or therapeutic agent. Due to potential technological interest over the last decade, PtNPs have attracted much attention in the field of anticancer research. PtNPs, when conjugated with many functionalizing agents such as polymers, ligands, drugs, peptides, and surfactants, exhibit improved targeting and reduced cytotoxic effects in various cancers. The PtNPs conjugated with folic acid, graphene oxide, and iron NPs are gained more attention due to their stability, large surface area, and reduced toxicity. To achieve this goal, PtNPs are co-loaded with drugs or other modalities that offer an opportunity for multimodal activity in the frame of treating cancer types focusing on breast, blood, lung, ovarian, skin, liver, etc. However, a review of PtNPs’ function in diagnosis and treatment is still lacking. In this review, the effectiveness of PtNPs toward inducing and elevating death of the cancerous cells proving its delivery approaches and antitumor nature, concluding with future perspectives, are summarized.

中文翻译：

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过去十年铂纳米粒子在抗癌治疗中的应用：综述

对新功能纳米材料的探索是纳米科学和纳米技术的定义目的之一。大量金属纳米粒子 (NPs) 被广泛用于生物医学应用。金属纳米颗粒，尤其是铂纳米颗粒 (PtNPs)，具有显着的特性，使其成为潜在的诊断或治疗剂候选者。由于过去十年潜在的技术兴趣，PtNPs 在抗癌研究领域引起了广泛关注。PtNPs 与许多功能化试剂（如聚合物、配体、药物、肽和表面活性剂）结合时，在各种癌症中表现出更好的靶向性和降低的细胞毒性作用。与叶酸、氧化石墨烯和铁纳米粒子结合的 PtNPs 因其稳定性、大表面积和低毒性而受到更多关注。为了实现这一目标，PtNPs 与药物或其他方式共同加载，这些方式为在治疗癌症类型的框架内提供多模式活动的机会，重点是乳腺癌、血液、肺癌、卵巢癌、皮肤癌、肝癌等。然而，回顾PtNPs在诊断和治疗中的功能仍然缺乏。在这篇综述中，总结了 PtNPs 在诱导和提高癌细胞死亡方面的有效性，证明了其递送方法和抗肿瘤性质，并总结了未来的前景。