Measurement ( IF 5.6 ) Pub Date : 2021-09-11 , DOI: 10.1016/j.measurement.2021.110135 Martin W. Sifuna 1 , Marlin R. Baidillah 1 , Daisuke Kawashima 1 , Panji N. Darma 1 , Eddy O. Odari 2 , Masahiro Takei 1
A sensitive frequency f margin SFM has been determined for quantification of aggregated interstitial protein concentrations Фprot by frequency difference electrical impedance tomography fd-EIT. Impedances of increasing Фprot of albumin-globulin mixtures in phantoms were measured and changes in protein’s adjacent f point conductivity Δσadj and loss factor Δε''adj plotted against f to determine a Фprot SFM fsen where σadj and ε''adj change significantly with Фprot. Results show that the Δσadj and Δε''adj dropped rapidly with increase in f up to f = 10 kHz then gradually to f = 100 kHz. The σ and ε” were only sensitive to Фprot as f increased from 1 to 10 kHz. For fd-EIT, optimum reference frequency fref was set at 100 kHz. At fsen = 1 kHz against fref, fd-EIT reconstructed σ due to 30% increase in Фprot with area ratio error ARE = 4.1% and a position error PE = 0.1 [-].
中文翻译:
通过 fd-电阻抗断层扫描确定聚集蛋白浓度量化的敏感频率裕度
通过频差电阻抗断层扫描fd- EIT确定了一个敏感的频率f margin SFM 来量化聚集的间质蛋白浓度Ф prot。测量了体模中白蛋白-球蛋白混合物的Ф prot增加的阻抗,并将蛋白质相邻f点电导率 Δ σ adj和损耗因子 Δ ε'' adj 的变化与f作图以确定Ф prot SFM f sen,其中σ adj和ε' '形容词随Ф prot变化显着。结果表明,Δσ adj和Δ ε'' adj随f 的增加而迅速下降,直到f = 10 kHz,然后逐渐下降到f = 100 kHz。当f从 1 kHz 增加到 10 kHz 时,σ和ε”仅对Ф prot敏感。对于fd -EIT,最佳参考频率f ref设置为 100 kHz。在f sen = 1 kHz 相对于f ref 时,fd -EIT 重建σ由于Ф prot增加 30% ,面积比误差ARE = 4.1%,位置误差PE = 0.1 [-]。