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Synthesis and physicochemical characterization of Lu and Sm sesquioxide nanoparticles by precipitation-calcination and pulsed laser ablation in liquids
Materials Chemistry and Physics ( IF 4.6 ) Pub Date : 2021-09-11 , DOI: 10.1016/j.matchemphys.2021.125229
Alejandra Ancira-Cortez 1, 2 , Diana Trujillo-Benítez 1, 2 , Nallely Jiménez-Mancilla 1, 3 , Clara Santos-Cuevas 1 , Enrique Morales-Avila 2 , Guillermina Ferro-Flores 1
Affiliation  

This study synthesized peptide-functionalized Lu and Sm sesquioxide nanoparticles by precipitation-calcination (P–C) and pulsed laser ablation in liquids (PLAL) to evaluate their physicochemical properties after neutron activation. Nanoparticles were obtained by precipitation in an alkaline solution, followed by centrifugation, drying, calcination, and functionalization with peptides (three or eighteen amino acids). For the PLAL nanoparticle synthesis, tablets made of Lu2O3 and Sm2O3 powders were immersed in peptide solutions and laser-irradiated (Nd:YAG) for 30 min, followed by ultracentrifugation as a purification process. The nanosystems were analyzed using transmission electron microscopy, high-resolution transmission electron microscopy, selected area electron diffraction, X-ray diffraction, differential scanning calorimetry-thermogravimetry, and FTIR and UV–Vis spectroscopies. Luminescence was evaluated after nanoparticle neutron activation using an optical imaging device (CCD camera). The Lu2O3 and Sm2O3 nanoparticles synthesized by P–C showed a quasi-spherical and well-defined morphology, with a monomodal and monodispersed size distribution (30.05–44.83 nm) and highly crystalline patterns (cubic m3 space group). In contrast, the micrographs of the Lu and Sm sesquioxide nanoparticles obtained by PLAL showed two distinct populations, namely, one of well-defined and dispersed spherical particles (62.35–75.02 nm), and the other of precursor material fragments without defined form or size (>2 μm). The diffractograms of the PLAL synthesis products were wide and not well defined due to the amorphous material that was simultaneously produced with the crystalline nanoparticles, which affected the detection of luminescence. The nanosystems prepared by P–C were obtained in high yields (70% for Lu2O3 and 90% for Sm2O3) and with optimal physicochemical characteristics, significantly impacting the radioluminescence properties of the nanoparticles (emissions of ∼615 nm for Lu2O3 and ∼758 nm for Sm2O3). P–C is a suitable method for producing peptide-functionalized [177Lu]Lu and [153Sm]Sm sesquioxide nanoparticles for dual imaging (nuclear and optical imaging) in potential theranostic applications.



中文翻译:

在液体中沉淀煅烧和脉冲激光烧蚀合成 Lu 和 Sm 倍半氧化物纳米粒子的合成和物理化学表征

本研究通过沉淀煅烧 (P-C) 和液体脉冲激光烧蚀 (PLAL) 合成了肽功能化的 Lu 和 Sm 倍半氧化物纳米颗粒,以评估它们在中子活化后的理化性质。通过在碱性溶液中沉淀,然后离心、干燥、煅烧和用肽(三个或十八个氨基酸)功能化来获得纳米颗粒。对于 PLAL 纳米颗粒合成,由 Lu 2 O 3和 Sm 2 O 3制成的片剂将粉末浸入肽溶液中并进行激光照射(Nd:YAG)30 分钟,然后进行超速离心作为纯化过程。使用透射电子显微镜、高分辨率透射电子显微镜、选区电子衍射、X 射线衍射、差示扫描量热-热重分析、FTIR 和紫外-可见光谱分析纳米系统。使用光学成像设备(CCD 相机)在纳米粒子中子激活后评估发光。由 P-C 合成的 Lu 2 O 3和 Sm 2 O 3纳米颗粒显示出准球形和明确定义的形态,具有单峰和单分散尺寸分布(30.05-44.83 nm)和高度结晶图案(立方米3空间群)。相比之下,通过 PLAL 获得的 Lu 和 Sm 倍半氧化物纳米颗粒的显微照片显示出两个不同的群体,即一个明确和分散的球形颗粒(62.35-75.02 nm),另一个没有确定形式或大小的前体材料碎片(>2 微米)。由于与结晶纳米颗粒同时产生的无定形材料影响了发光的检测,PLAL 合成产物的衍射图很宽并且没有很好地定义。由 P-C 制备的纳米系统以高产率获得(Lu 2 O 3为 70 %,Sm 2 O 3为 90%) 并具有最佳的物理化学特性,显着影响纳米粒子的辐射发光特性(Lu 2 O 3 的发射率约为615 nm,Sm 2 O 3 的发射率约为 758 nm )。P-C 是一种合适的方法,可用于生产肽功能化的 [ 177 Lu] Lu 和 [ 153 Sm] Sm 倍半氧化物纳米颗粒,用于潜在治疗诊断应用中的双重成像(核和光学成像)。

更新日期:2021-09-13
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