Activation of neutrophils is necessary for the protection of the host against microbial infection. This property can be used as mode of therapy for cancer treatment. Neutrophils have conflicting dual functions in cancer as either a tumor promoter or inhibitor. Neutrophil-based drug delivery has achieved increased attention in pre-clinical models. This review addresses in detail the different neutrophil constituents, the conflicting function of neutrophils and activation of the neutrophil as an important target of therapy for cancer treatment, and use of neutrophils or neutrophil membrane-derived vesicles as vehicles for drug delivery and targeting.

中文翻译：

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中性粒细胞作为癌症治疗的新兴治疗靶点和工具

中性粒细胞的激活是保护宿主免受微生物感染所必需的。该特性可用作癌症治疗的治疗模式。中性粒细胞在癌症中作为肿瘤促进剂或抑制剂具有相互矛盾的双重功能。基于中性粒细胞的药物递送在临床前模型中引起了越来越多的关注。本综述详细讨论了不同的中性粒细胞成分、中性粒细胞的冲突功能和中性粒细胞作为癌症治疗重要靶点的激活，以及中性粒细胞或中性粒细胞膜衍生囊泡作为药物递送和靶向载体的用途。