Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical amnestic Alzheimer's disease and 16 healthy Control participants. A validated assessment, the Autobiographical Interview, was employed to explore autobiographical memory performance across the lifespan under free and probed recall conditions. Relative to Controls, LPA patients showed global impairments across all time periods for free recall, scoring at the same level as disease-matched cases of Alzheimer's Disease. Importantly, these retrieval deficits persisted in LPA, even when structured probing was provided, and could not be explained by overall level of language disruption or amount of information generated during autobiographical narration. Autobiographical memory impairments in LPA related to grey matter intensity decrease in predominantly posterior parietal brain regions implicated in memory retrieval. Together, our results suggest that episodic memory disturbances may be an under-appreciated clinical feature of LPA.

尽管主要以语言障碍为特征，但越来越多的证据表明在语言障碍进行性失语症 (LPA) 中存在发作性健忘症。这种记忆障碍是否延伸到疾病发作前编码的信息仍不清楚。为了解决这个问题，我们检查了 10 名 LPA 患者的自传记忆，并与 18 名典型的失忆性阿尔茨海默病和 16 名健康对照参与者进行了对比。一项经过验证的评估，即自传式访谈，被用来探索在自由和探索性回忆条件下在整个生命周期中的自传记忆表现。相对于对照组，LPA 患者在所有时间段的自由回忆中都表现出整体损伤，得分与疾病匹配的阿尔茨海默病病例相同。重要的是，这些检索缺陷在 LPA 中持续存在，即使提供了结构化的探究，也无法用语言中断的整体水平或自传式叙述过程中产生的信息量来解释。LPA 中的自传体记忆障碍与灰质强度降低有关，主要是与记忆检索有关的后顶叶区域。总之，我们的结果表明，情景记忆障碍可能是 LPA 的一个未被充分认识的临床特征。