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Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial
Heart ( IF 5.7 ) Pub Date : 2022-06-01 , DOI: 10.1136/heartjnl-2021-319716 Yong Liu 1, 2 , Ning Tan 1, 2 , Yong Huo 3 , Shiqun Chen 1, 2 , Jin Liu 1, 2 , Yun-Dai Chen 4 , Keng Wu 5 , Guifu Wu 6 , Kaihong Chen 7 , Jianfeng Ye 8 , Yan Liang 9 , Xinwu Feng 10 , Shaohong Dong 11 , Qiming Wu 12 , Xianhua Ye 13 , Hesong Zeng 14 , Minzhou Zhang 15 , Min Dai 16 , Chong-Yang Duan 17 , Guoli Sun 1, 2 , Yibo He 1, 2 , Feier Song 1, 2 , Zhaodong Guo 1, 2 , Ping-Yan Chen 16 , Junbo Ge 18 , Ying Xian 19 , Jiyan Chen 2, 20
Heart ( IF 5.7 ) Pub Date : 2022-06-01 , DOI: 10.1136/heartjnl-2021-319716 Yong Liu 1, 2 , Ning Tan 1, 2 , Yong Huo 3 , Shiqun Chen 1, 2 , Jin Liu 1, 2 , Yun-Dai Chen 4 , Keng Wu 5 , Guifu Wu 6 , Kaihong Chen 7 , Jianfeng Ye 8 , Yan Liang 9 , Xinwu Feng 10 , Shaohong Dong 11 , Qiming Wu 12 , Xianhua Ye 13 , Hesong Zeng 14 , Minzhou Zhang 15 , Min Dai 16 , Chong-Yang Duan 17 , Guoli Sun 1, 2 , Yibo He 1, 2 , Feier Song 1, 2 , Zhaodong Guo 1, 2 , Ping-Yan Chen 16 , Junbo Ge 18 , Ying Xian 19 , Jiyan Chen 2, 20
Affiliation
Objective To evaluate the efficacy of aggressive hydration compared with general hydration for contrast-induced acute kidney injury (CI-AKI) prevention among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). Methods The Aggressive hydraTion in patients with STEMI undergoing pPCI to prevenT Contrast-Induced Acute Kidney Injury study is an open-label, randomised controlled study at 15 teaching hospitals in China. A total of 560 adult patients were randomly assigned (1:1) to receive aggressive hydration or general hydration treatment. Aggressive hydration group received preprocedural loading dose of 125/250 mL normal saline within 30 min, followed by postprocedural hydration performed for 4 hours under left ventricular end-diastolic pressure guidance and additional hydration until 24 hours after pPCI. General hydration group received ≤500 mL 0.9% saline at 1 mL/kg/hour for 6 hours after randomisation. The primary end point is CI-AKI, defined as a >25% or 0.5 mg/dL increased in serum creatinine from baseline during the first 48–72 hours after primary angioplasty. The safety end point is acute heart failure. Results From July 2014 to May 2018, 469 patients were enrolled in the final analysis. CI-AKI occurred less frequently in aggressive hydration group than in general hydration group (21.8% vs 31.1%; risk ratio (RR) 0.70, 95% CI 0.52 to 0.96). Acute heart failure did not significantly differ between the aggressive hydration group and the general hydration group (8.1% vs 6.4%, RR 1.13, 95% CI 0.66 to 2.44). Several subgroup analysis showed the better effect of aggressive hydration in CI-AKI prevention in male, renal insufficient and non-anterior myocardial infarction participants. Conclusions Comparing with general hydration, the peri-operative aggressive hydration seems to be safe and effective in preventing CI-AKI among patients with STEMI undergoing pPCI. Data are available on reasonable request. Data are available upon reasonable request.
更新日期：2022-05-25
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